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Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.

Publication ,  Journal Article
Shoda, LK; Battista, C; Siler, SQ; Pisetsky, DS; Watkins, PB; Howell, BA
Published in: Gene Regul Syst Bio
2017

Drug-induced liver injury (DILI) remains an adverse event of significant concern for drug development and marketed drugs, and the field would benefit from better tools to identify liver liabilities early in development and/or to mitigate potential DILI risk in otherwise promising drugs. DILIsym software takes a quantitative systems toxicology approach to represent DILI in pre-clinical species and in humans for the mechanistic investigation of liver toxicity. In addition to multiple intrinsic mechanisms of hepatocyte toxicity (ie, oxidative stress, bile acid accumulation, mitochondrial dysfunction), DILIsym includes the interaction between hepatocytes and cells of the innate immune response in the amplification of liver injury and in liver regeneration. The representation of innate immune responses, detailed here, consolidates much of the available data on the innate immune response in DILI within a single framework and affords the opportunity to systematically investigate the contribution of the innate response to DILI.

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Published In

Gene Regul Syst Bio

DOI

ISSN

1177-6250

Publication Date

2017

Volume

11

Start / End Page

1177625017696074

Location

United States

Related Subject Headings

  • 3105 Genetics
  • 0604 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shoda, L. K., Battista, C., Siler, S. Q., Pisetsky, D. S., Watkins, P. B., & Howell, B. A. (2017). Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses. Gene Regul Syst Bio, 11, 1177625017696074. https://doi.org/10.1177/1177625017696074
Shoda, Lisl Km, Christina Battista, Scott Q. Siler, David S. Pisetsky, Paul B. Watkins, and Brett A. Howell. “Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.Gene Regul Syst Bio 11 (2017): 1177625017696074. https://doi.org/10.1177/1177625017696074.
Shoda LK, Battista C, Siler SQ, Pisetsky DS, Watkins PB, Howell BA. Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses. Gene Regul Syst Bio. 2017;11:1177625017696074.
Shoda, Lisl Km, et al. “Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.Gene Regul Syst Bio, vol. 11, 2017, p. 1177625017696074. Pubmed, doi:10.1177/1177625017696074.
Shoda LK, Battista C, Siler SQ, Pisetsky DS, Watkins PB, Howell BA. Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses. Gene Regul Syst Bio. 2017;11:1177625017696074.

Published In

Gene Regul Syst Bio

DOI

ISSN

1177-6250

Publication Date

2017

Volume

11

Start / End Page

1177625017696074

Location

United States

Related Subject Headings

  • 3105 Genetics
  • 0604 Genetics