Skip to main content
Journal cover image

Dual-axis optical coherence tomography for deep tissue imaging.

Publication ,  Journal Article
Zhao, Y; Eldridge, WJ; Maher, JR; Kim, S; Crose, M; Ibrahim, M; Levinson, H; Wax, A
Published in: Optics letters
June 2017

We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a rate of 4 frames (B-scans) per second. DA-OCT differs from ms2/LCI in that the dual axes intersect at a shallower depth (∼1  mm). This difference, coupled with the faster scanning speed, shifts the detection priority from multiply scattered to ballistic light. The utility of this approach was demonstrated by imaging both ex vivo porcine ear skin and in vivo rat skin from a McFarlane flap model. The enhanced penetration depth provided by the DA-OCT system will be beneficial to various clinical applications in dermatology and surgery.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

June 2017

Volume

42

Issue

12

Start / End Page

2302 / 2305

Related Subject Headings

  • Tomography, Optical Coherence
  • Swine
  • Surgical Flaps
  • Skin
  • Rats
  • Optics
  • Lighting
  • Light
  • Interferometry
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhao, Y., Eldridge, W. J., Maher, J. R., Kim, S., Crose, M., Ibrahim, M., … Wax, A. (2017). Dual-axis optical coherence tomography for deep tissue imaging. Optics Letters, 42(12), 2302–2305. https://doi.org/10.1364/ol.42.002302
Zhao, Yang, Will J. Eldridge, Jason R. Maher, Sanghoon Kim, Michael Crose, Mohamed Ibrahim, Howard Levinson, and Adam Wax. “Dual-axis optical coherence tomography for deep tissue imaging.Optics Letters 42, no. 12 (June 2017): 2302–5. https://doi.org/10.1364/ol.42.002302.
Zhao Y, Eldridge WJ, Maher JR, Kim S, Crose M, Ibrahim M, et al. Dual-axis optical coherence tomography for deep tissue imaging. Optics letters. 2017 Jun;42(12):2302–5.
Zhao, Yang, et al. “Dual-axis optical coherence tomography for deep tissue imaging.Optics Letters, vol. 42, no. 12, June 2017, pp. 2302–05. Epmc, doi:10.1364/ol.42.002302.
Zhao Y, Eldridge WJ, Maher JR, Kim S, Crose M, Ibrahim M, Levinson H, Wax A. Dual-axis optical coherence tomography for deep tissue imaging. Optics letters. 2017 Jun;42(12):2302–2305.
Journal cover image

Published In

Optics letters

DOI

EISSN

1539-4794

ISSN

0146-9592

Publication Date

June 2017

Volume

42

Issue

12

Start / End Page

2302 / 2305

Related Subject Headings

  • Tomography, Optical Coherence
  • Swine
  • Surgical Flaps
  • Skin
  • Rats
  • Optics
  • Lighting
  • Light
  • Interferometry
  • Animals