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Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys.

Publication ,  Journal Article
Nelson, CS; Cruz, DV; Tran, D; Bialas, KM; Stamper, L; Wu, H; Gilbert, M; Blair, R; Alvarez, X; Itell, H; Chen, M; Deshpande, A; Chiuppesi, F ...
Published in: JCI Insight
July 6, 2017

Human cytomegalovirus (HCMV) is the most common congenital infection and a known cause of microcephaly, sensorineural hearing loss, and cognitive impairment among newborns worldwide. Natural maternal HCMV immunity reduces the incidence of congenital infection, but does not prevent the disease altogether. We employed a nonhuman primate model of congenital CMV infection to investigate the ability of preexisting antibodies to protect against placental CMV transmission in the setting of primary maternal infection and subsequent viremia, which is required for placental virus exposure. Pregnant, CD4+ T cell-depleted, rhesus CMV-seronegative (RhCMV-seronegative) rhesus monkeys were treated with either standardly produced hyperimmune globulin (HIG) from RhCMV-seropositive macaques or dose-optimized, potently RhCMV-neutralizing HIG prior to intravenous challenge with an RhCMV mixture. HIG passive infusion provided complete protection against fetal loss in both groups. The dose-optimized, RhCMV-neutralizing HIG additionally inhibited placental transmission of RhCMV and reduced viral replication and diversity. Our findings suggest that the presence of durable and potently neutralizing antibodies at the time of primary infection can prevent transmission of systemically replicating maternal RhCMV to the developing fetus, and therefore should be a primary target of vaccines to eliminate this neonatal infection.

Duke Scholars

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Published In

JCI Insight

DOI

EISSN

2379-3708

Publication Date

July 6, 2017

Volume

2

Issue

13

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nelson, C. S., Cruz, D. V., Tran, D., Bialas, K. M., Stamper, L., Wu, H., … Permar, S. R. (2017). Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. JCI Insight, 2(13). https://doi.org/10.1172/jci.insight.94002
Nelson, Cody S., Diana Vera Cruz, Dollnovan Tran, Kristy M. Bialas, Lisa Stamper, Huali Wu, Margaret Gilbert, et al. “Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys.JCI Insight 2, no. 13 (July 6, 2017). https://doi.org/10.1172/jci.insight.94002.
Nelson CS, Cruz DV, Tran D, Bialas KM, Stamper L, Wu H, et al. Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. JCI Insight. 2017 Jul 6;2(13).
Nelson, Cody S., et al. “Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys.JCI Insight, vol. 2, no. 13, July 2017. Pubmed, doi:10.1172/jci.insight.94002.
Nelson CS, Cruz DV, Tran D, Bialas KM, Stamper L, Wu H, Gilbert M, Blair R, Alvarez X, Itell H, Chen M, Deshpande A, Chiuppesi F, Wussow F, Diamond DJ, Vandergrift N, Walter MR, Barry PA, Cohen-Wolkowiez M, Koelle K, Kaur A, Permar SR. Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. JCI Insight. 2017 Jul 6;2(13).

Published In

JCI Insight

DOI

EISSN

2379-3708

Publication Date

July 6, 2017

Volume

2

Issue

13

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences