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Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis.

Publication ,  Journal Article
Strickland, KC; Vivero, M; Jo, VY; Lowe, AC; Hollowell, M; Qian, X; Wieczorek, TJ; French, CA; Teot, LA; Sadow, PM; Alexander, EK; Cibas, ES ...
Published in: Thyroid
October 2016

BACKGROUND: The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has been proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) in recognition of the indolent behavior of this tumor. The ability to differentiate NIFTP from classical papillary thyroid carcinoma (cPTC) by fine-needle aspiration (FNA) would facilitate conservative management for NIFTP. The aim of this study was to determine if NIFTP can be distinguished prospectively from cPTC. METHODS: From June 2015 to January 2016, thyroid FNAs with a diagnosis of "malignant" or "suspicious for malignancy" were prospectively scored for features associated with NIFTP/FVPTC (microfollicular architecture) or cPTC (papillae, psammomatous calcifications, sheet-like architecture, and nuclear pseudoinclusions) and categorized as NIFTP/FVPTC, cPTC, or indeterminate. Results were correlated with subsequent histologic diagnoses. RESULTS: The study included 52 patients with 56 resected nodules with a cytologic diagnosis of "malignant" (43/56) or "suspicious for malignancy" (13/56). Forty-nine patients (94%) underwent initial total thyroidectomy. Histopathologic diagnoses included 42 cPTC, 8 NIFTP, 3 invasive FVPTC, 2 follicular adenomas, and 1 poorly differentiated carcinoma. Excluding 7 indeterminate cases, 89% (8/9) of nodules classified as NIFTP/FVPTC on FNA demonstrated follicular-patterned lesions on histology (5 NIFTP, 1 invasive FVPTC, 2 follicular adenomas). Cytopathologists prospectively identified cPTC in 95% (38/40) of cases. CONCLUSIONS: In thyroid FNAs with cytologic features concerning for PTC, NIFTP/FVPTC can be distinguished from cPTC in most cases by assessing a limited number of features. Therefore, it is both feasible and appropriate to attempt to separate NIFTP/FVPTC from cPTC on FNA to promote appropriate clinical management.

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Published In

Thyroid

DOI

EISSN

1557-9077

Publication Date

October 2016

Volume

26

Issue

10

Start / End Page

1466 / 1471

Location

United States

Related Subject Headings

  • Young Adult
  • Thyroidectomy
  • Thyroid Nodule
  • Thyroid Neoplasms
  • Thyroid Gland
  • Prospective Studies
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Strickland, K. C., Vivero, M., Jo, V. Y., Lowe, A. C., Hollowell, M., Qian, X., … Krane, J. F. (2016). Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis. Thyroid, 26(10), 1466–1471. https://doi.org/10.1089/thy.2016.0280
Strickland, Kyle C., Marina Vivero, Vickie Y. Jo, Alarice C. Lowe, Monica Hollowell, Xiaohua Qian, Tad J. Wieczorek, et al. “Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis.Thyroid 26, no. 10 (October 2016): 1466–71. https://doi.org/10.1089/thy.2016.0280.
Strickland KC, Vivero M, Jo VY, Lowe AC, Hollowell M, Qian X, et al. Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis. Thyroid. 2016 Oct;26(10):1466–71.
Strickland, Kyle C., et al. “Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis.Thyroid, vol. 26, no. 10, Oct. 2016, pp. 1466–71. Pubmed, doi:10.1089/thy.2016.0280.
Strickland KC, Vivero M, Jo VY, Lowe AC, Hollowell M, Qian X, Wieczorek TJ, French CA, Teot LA, Sadow PM, Alexander EK, Cibas ES, Barletta JA, Krane JF. Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis. Thyroid. 2016 Oct;26(10):1466–1471.
Journal cover image

Published In

Thyroid

DOI

EISSN

1557-9077

Publication Date

October 2016

Volume

26

Issue

10

Start / End Page

1466 / 1471

Location

United States

Related Subject Headings

  • Young Adult
  • Thyroidectomy
  • Thyroid Nodule
  • Thyroid Neoplasms
  • Thyroid Gland
  • Prospective Studies
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Humans