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Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines.

Publication ,  Journal Article
Middleton, DM; Li, JY; Chen, SD; White, LE; Dickson, PI; Matthew Ellinwood, N; Provenzale, JM
Published in: Neuroradiol J
October 2017

Purpose We compared fractional anisotropy and radial diffusivity measurements between pediatric canines affected with mucopolysaccharidosis I and pediatric control canines. We hypothesized that lower fractional anisotropy and higher radial diffusivity values, consistent with dysmyelination, would be present in the mucopolysaccharidosis I cohort. Methods Six canine brains, three affected with mucopolysaccharidosis I and three unaffected, were euthanized at 7 weeks and imaged using a 7T small-animal magnetic resonance imaging system. Average fractional anisotropy and radial diffusivity values were calculated for four white-matter regions based on 100 regions of interest per region per specimen. A 95% confidence interval was calculated for each mean value. Results No difference was seen in fractional anisotropy or radial diffusivity values between mucopolysaccharidosis affected and unaffected brains in any region. In particular, the 95% confidence intervals for mucopolysaccharidosis affected and unaffected canines frequently overlapped for both fractional anisotropy and radial diffusivity measurements. In addition, in some brain regions a large range of fractional anisotropy and radial diffusivity values were seen within the same cohort. Conclusion The fractional anisotropy and radial diffusivity values of white matter did not differ between pediatric mucopolysaccharidosis affected canines and pediatric control canines. Possible explanations include: (a) a lack of white matter tissue differences between mucopolysaccharidosis affected and unaffected brains at early disease stages; (b) diffusion tensor imaging does not detect any existing differences; (c) inflammatory processes such as astrogliosis produce changes that offset the decreased fractional anisotropy values and increased radial diffusivity values that are expected in dysmyelination; and (d) our sample size was insufficient to detect differences. Further studies correlating diffusion tensor imaging findings to histology are warranted.

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Published In

Neuroradiol J

DOI

EISSN

2385-1996

Publication Date

October 2017

Volume

30

Issue

5

Start / End Page

454 / 460

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Mucopolysaccharidosis I
  • Image Processing, Computer-Assisted
  • Dogs
  • Dog Diseases
  • Diffusion Tensor Imaging
  • Anisotropy
  • Animals
  • 1109 Neurosciences
 

Citation

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Middleton, D. M., Li, J. Y., Chen, S. D., White, L. E., Dickson, P. I., Matthew Ellinwood, N., & Provenzale, J. M. (2017). Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines. Neuroradiol J, 30(5), 454–460. https://doi.org/10.1177/1971400917718844
Middleton, Dana M., Jonathan Y. Li, Steven D. Chen, Leonard E. White, Patricia I. Dickson, N. Matthew Ellinwood, and James M. Provenzale. “Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines.Neuroradiol J 30, no. 5 (October 2017): 454–60. https://doi.org/10.1177/1971400917718844.
Middleton DM, Li JY, Chen SD, White LE, Dickson PI, Matthew Ellinwood N, et al. Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines. Neuroradiol J. 2017 Oct;30(5):454–60.
Middleton, Dana M., et al. “Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines.Neuroradiol J, vol. 30, no. 5, Oct. 2017, pp. 454–60. Pubmed, doi:10.1177/1971400917718844.
Middleton DM, Li JY, Chen SD, White LE, Dickson PI, Matthew Ellinwood N, Provenzale JM. Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines. Neuroradiol J. 2017 Oct;30(5):454–460.
Journal cover image

Published In

Neuroradiol J

DOI

EISSN

2385-1996

Publication Date

October 2017

Volume

30

Issue

5

Start / End Page

454 / 460

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Mucopolysaccharidosis I
  • Image Processing, Computer-Assisted
  • Dogs
  • Dog Diseases
  • Diffusion Tensor Imaging
  • Anisotropy
  • Animals
  • 1109 Neurosciences