Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST).
Publication
, Journal Article
Wu, Q; Fenton, BA; Wojtaszek, JL; Zhou, P
Published in: Chem Commun (Camb)
July 27, 2017
CEST-NMR spectroscopy is a powerful tool for probing the conformational dynamics of macromolecules. We present a HNdec-CEST experiment that simplifies the relaxation matrix, reduces fitting parameters, and enhances signal resolution. Importantly, fitting of HNdec-CEST profiles enables robust extraction of exchange rates as well as excited-state chemical shifts and populations.
Duke Scholars
Published In
Chem Commun (Camb)
DOI
EISSN
1364-548X
Publication Date
July 27, 2017
Volume
53
Issue
61
Start / End Page
8541 / 8544
Location
England
Related Subject Headings
- Organic Chemistry
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Wu, Q., Fenton, B. A., Wojtaszek, J. L., & Zhou, P. (2017). Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST). Chem Commun (Camb), 53(61), 8541–8544. https://doi.org/10.1039/c7cc05021f
Wu, Qinglin, Benjamin A. Fenton, Jessica L. Wojtaszek, and Pei Zhou. “Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST).” Chem Commun (Camb) 53, no. 61 (July 27, 2017): 8541–44. https://doi.org/10.1039/c7cc05021f.
Wu Q, Fenton BA, Wojtaszek JL, Zhou P. Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST). Chem Commun (Camb). 2017 Jul 27;53(61):8541–4.
Wu, Qinglin, et al. “Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST).” Chem Commun (Camb), vol. 53, no. 61, July 2017, pp. 8541–44. Pubmed, doi:10.1039/c7cc05021f.
Wu Q, Fenton BA, Wojtaszek JL, Zhou P. Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST). Chem Commun (Camb). 2017 Jul 27;53(61):8541–8544.
Published In
Chem Commun (Camb)
DOI
EISSN
1364-548X
Publication Date
July 27, 2017
Volume
53
Issue
61
Start / End Page
8541 / 8544
Location
England
Related Subject Headings
- Organic Chemistry
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences