A structural perspective on the where, how, why, and what of nucleosome positioning.
Publication
, Journal Article
Arya, G; Maitra, A; Grigoryev, SA
Published in: Journal of biomolecular structure & dynamics
June 2010
The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation.
Duke Scholars
Published In
Journal of biomolecular structure & dynamics
DOI
EISSN
1538-0254
ISSN
0739-1102
Publication Date
June 2010
Volume
27
Issue
6
Start / End Page
803 / 820
Related Subject Headings
- Nucleosomes
- Nucleic Acid Conformation
- Humans
- Enzymes
- Chromatin Assembly and Disassembly
- Biophysics
- Base Sequence
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Arya, G., Maitra, A., & Grigoryev, S. A. (2010). A structural perspective on the where, how, why, and what of nucleosome positioning. Journal of Biomolecular Structure & Dynamics, 27(6), 803–820. https://doi.org/10.1080/07391102.2010.10508585
Arya, Gaurav, Arijit Maitra, and Sergei A. Grigoryev. “A structural perspective on the where, how, why, and what of nucleosome positioning.” Journal of Biomolecular Structure & Dynamics 27, no. 6 (June 2010): 803–20. https://doi.org/10.1080/07391102.2010.10508585.
Arya G, Maitra A, Grigoryev SA. A structural perspective on the where, how, why, and what of nucleosome positioning. Journal of biomolecular structure & dynamics. 2010 Jun;27(6):803–20.
Arya, Gaurav, et al. “A structural perspective on the where, how, why, and what of nucleosome positioning.” Journal of Biomolecular Structure & Dynamics, vol. 27, no. 6, June 2010, pp. 803–20. Epmc, doi:10.1080/07391102.2010.10508585.
Arya G, Maitra A, Grigoryev SA. A structural perspective on the where, how, why, and what of nucleosome positioning. Journal of biomolecular structure & dynamics. 2010 Jun;27(6):803–820.
Published In
Journal of biomolecular structure & dynamics
DOI
EISSN
1538-0254
ISSN
0739-1102
Publication Date
June 2010
Volume
27
Issue
6
Start / End Page
803 / 820
Related Subject Headings
- Nucleosomes
- Nucleic Acid Conformation
- Humans
- Enzymes
- Chromatin Assembly and Disassembly
- Biophysics
- Base Sequence
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology