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A structural perspective on the where, how, why, and what of nucleosome positioning.

Publication ,  Journal Article
Arya, G; Maitra, A; Grigoryev, SA
Published in: Journal of biomolecular structure & dynamics
June 2010

The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation.

Duke Scholars

Published In

Journal of biomolecular structure & dynamics

DOI

EISSN

1538-0254

ISSN

0739-1102

Publication Date

June 2010

Volume

27

Issue

6

Start / End Page

803 / 820

Related Subject Headings

  • Nucleosomes
  • Nucleic Acid Conformation
  • Humans
  • Enzymes
  • Chromatin Assembly and Disassembly
  • Biophysics
  • Base Sequence
  • Animals
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Arya, G., Maitra, A., & Grigoryev, S. A. (2010). A structural perspective on the where, how, why, and what of nucleosome positioning. Journal of Biomolecular Structure & Dynamics, 27(6), 803–820. https://doi.org/10.1080/07391102.2010.10508585
Arya, Gaurav, Arijit Maitra, and Sergei A. Grigoryev. “A structural perspective on the where, how, why, and what of nucleosome positioning.Journal of Biomolecular Structure & Dynamics 27, no. 6 (June 2010): 803–20. https://doi.org/10.1080/07391102.2010.10508585.
Arya G, Maitra A, Grigoryev SA. A structural perspective on the where, how, why, and what of nucleosome positioning. Journal of biomolecular structure & dynamics. 2010 Jun;27(6):803–20.
Arya, Gaurav, et al. “A structural perspective on the where, how, why, and what of nucleosome positioning.Journal of Biomolecular Structure & Dynamics, vol. 27, no. 6, June 2010, pp. 803–20. Epmc, doi:10.1080/07391102.2010.10508585.
Arya G, Maitra A, Grigoryev SA. A structural perspective on the where, how, why, and what of nucleosome positioning. Journal of biomolecular structure & dynamics. 2010 Jun;27(6):803–820.

Published In

Journal of biomolecular structure & dynamics

DOI

EISSN

1538-0254

ISSN

0739-1102

Publication Date

June 2010

Volume

27

Issue

6

Start / End Page

803 / 820

Related Subject Headings

  • Nucleosomes
  • Nucleic Acid Conformation
  • Humans
  • Enzymes
  • Chromatin Assembly and Disassembly
  • Biophysics
  • Base Sequence
  • Animals
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology