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Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements

Publication ,  Journal Article
Maitra, A; Arya, G
Published in: Physical Review Letters
March 12, 2010

Single-molecule force spectroscopy provides a powerful approach for investigating molecular transitions along specific reaction coordinates. Here, we present a general analytical model for extracting the intrinsic rates and activation free energies from force measurements on single molecules that is applicable to a broad range of pulling speeds and device stiffnesses. This model relaxes existing limitations to perform force measurements with soft pulling devices for proper theoretical analyses and, in fact, allows experiments to specifically exploit device stiffness as a control parameter in addition to pulling speed for a reliable estimation of energetic and kinetic parameters. © 2010 The American Physical Society.

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Published In

Physical Review Letters

DOI

EISSN

1079-7114

ISSN

0031-9007

Publication Date

March 12, 2010

Volume

104

Issue

10

Related Subject Headings

  • Thermodynamics
  • Spectrum Analysis
  • Models, Chemical
  • Kinetics
  • General Physics
  • Computer Simulation
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering
  • 09 Engineering
 

Citation

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Maitra, A., & Arya, G. (2010). Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements. Physical Review Letters, 104(10). https://doi.org/10.1103/PhysRevLett.104.108301
Maitra, A., and G. Arya. “Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements.” Physical Review Letters 104, no. 10 (March 12, 2010). https://doi.org/10.1103/PhysRevLett.104.108301.
Maitra, A., and G. Arya. “Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements.” Physical Review Letters, vol. 104, no. 10, Mar. 2010. Scopus, doi:10.1103/PhysRevLett.104.108301.

Published In

Physical Review Letters

DOI

EISSN

1079-7114

ISSN

0031-9007

Publication Date

March 12, 2010

Volume

104

Issue

10

Related Subject Headings

  • Thermodynamics
  • Spectrum Analysis
  • Models, Chemical
  • Kinetics
  • General Physics
  • Computer Simulation
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 40 Engineering
  • 09 Engineering