Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements
Publication
, Journal Article
Maitra, A; Arya, G
Published in: Physical Review Letters
March 12, 2010
Single-molecule force spectroscopy provides a powerful approach for investigating molecular transitions along specific reaction coordinates. Here, we present a general analytical model for extracting the intrinsic rates and activation free energies from force measurements on single molecules that is applicable to a broad range of pulling speeds and device stiffnesses. This model relaxes existing limitations to perform force measurements with soft pulling devices for proper theoretical analyses and, in fact, allows experiments to specifically exploit device stiffness as a control parameter in addition to pulling speed for a reliable estimation of energetic and kinetic parameters. © 2010 The American Physical Society.
Duke Scholars
Published In
Physical Review Letters
DOI
EISSN
1079-7114
ISSN
0031-9007
Publication Date
March 12, 2010
Volume
104
Issue
10
Related Subject Headings
- Thermodynamics
- Spectrum Analysis
- Models, Chemical
- Kinetics
- General Physics
- Computer Simulation
- 51 Physical sciences
- 49 Mathematical sciences
- 40 Engineering
- 09 Engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Maitra, A., & Arya, G. (2010). Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements. Physical Review Letters, 104(10). https://doi.org/10.1103/PhysRevLett.104.108301
Maitra, A., and G. Arya. “Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements.” Physical Review Letters 104, no. 10 (March 12, 2010). https://doi.org/10.1103/PhysRevLett.104.108301.
Maitra A, Arya G. Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements. Physical Review Letters. 2010 Mar 12;104(10).
Maitra, A., and G. Arya. “Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements.” Physical Review Letters, vol. 104, no. 10, Mar. 2010. Scopus, doi:10.1103/PhysRevLett.104.108301.
Maitra A, Arya G. Model accounting for the effects of pulling-device stiffness in the analyses of single-molecule force measurements. Physical Review Letters. 2010 Mar 12;104(10).
Published In
Physical Review Letters
DOI
EISSN
1079-7114
ISSN
0031-9007
Publication Date
March 12, 2010
Volume
104
Issue
10
Related Subject Headings
- Thermodynamics
- Spectrum Analysis
- Models, Chemical
- Kinetics
- General Physics
- Computer Simulation
- 51 Physical sciences
- 49 Mathematical sciences
- 40 Engineering
- 09 Engineering