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Lattice animal model of chromosome organization

Publication ,  Journal Article
Iyer, BVS; Arya, G
Published in: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
July 12, 2012

Polymer models tied together by constraints of looping and confinement have been used to explain many of the observed organizational characteristics of interphase chromosomes. Here we introduce a simple lattice animal representation of interphase chromosomes that combines the features of looping and confinement constraints into a single framework. We show through Monte Carlo simulations that this model qualitatively captures both the leveling off in the spatial distance between genomic markers observed in fluorescent in situ hybridization experiments and the inverse decay in the looping probability as a function of genomic separation observed in chromosome conformation capture experiments. The model also suggests that the collapsed state of chromosomes and their segregation into territories with distinct looping activities might be a natural consequence of confinement. © 2012 American Physical Society.

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Published In

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

DOI

EISSN

1550-2376

ISSN

1539-3755

Publication Date

July 12, 2012

Volume

86

Issue

1

Related Subject Headings

  • Models, Molecular
  • Models, Genetic
  • Models, Chemical
  • Models, Animal
  • Interphase
  • Fluids & Plasmas
  • Chromosomes
  • Animals
  • 09 Engineering
  • 02 Physical Sciences
 

Citation

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Iyer, B. V. S., & Arya, G. (2012). Lattice animal model of chromosome organization. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 86(1). https://doi.org/10.1103/PhysRevE.86.011911
Iyer, B. V. S., and G. Arya. “Lattice animal model of chromosome organization.” Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 86, no. 1 (July 12, 2012). https://doi.org/10.1103/PhysRevE.86.011911.
Iyer BVS, Arya G. Lattice animal model of chromosome organization. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2012 Jul 12;86(1).
Iyer, B. V. S., and G. Arya. “Lattice animal model of chromosome organization.” Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, vol. 86, no. 1, July 2012. Scopus, doi:10.1103/PhysRevE.86.011911.
Iyer BVS, Arya G. Lattice animal model of chromosome organization. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2012 Jul 12;86(1).

Published In

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

DOI

EISSN

1550-2376

ISSN

1539-3755

Publication Date

July 12, 2012

Volume

86

Issue

1

Related Subject Headings

  • Models, Molecular
  • Models, Genetic
  • Models, Chemical
  • Models, Animal
  • Interphase
  • Fluids & Plasmas
  • Chromosomes
  • Animals
  • 09 Engineering
  • 02 Physical Sciences