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SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors

Publication ,  Conference
Cleland, E; Brizel, D; Yoo, D; Dolguikh, M; Muradyan, N; Barboriak, D; Craciunescu, O
Published in: Medical Physics
January 1, 2008

Purpose: To determine the optimal flip angle combination (oFAc) that generates voxel‐based T10 values, the median T10 for primary and nodes [formula omitted], and its implications on vascular permeability (PERM) and extracellular volume fraction (EVF) in HN patients treated with targeted therapy and chemoradiation. Method and Materials: To generate voxel‐based T10, a gradient echo sequence was used on a 1.5 T scanner with TR=6.44 msec and FA of 10, 15, 20, 30, 45°. For different FA combinations, the voxel‐based values were calculated using CAD Sciences® (White Plains, NY). The average of the median T10 in muscle and fat [formula omitted] regions of interest (ROI) in 3 patients was calculated. Criteria for oFAc included minimal variation from published muscle and fat values at 1.5T, and minimum number of FA used for fitting. To determine [formula omitted], values from ROIs delineated by 2 users (A,B) were calculated. For 3 patients, the PERM and EVF from primary and nodes ROIs were calculated using T10 maps and [formula omitted]. Results: The 10–45° FAc was chosen for subsequent T10 mapping as it had the greatest percentage of fitted pixels (90% for muscle, 100% for fat, % 83 for primary, 72% for nodes) and a [formula omitted], and [formula omitted], compared to reported 0.870 and 0.260 sec for muscle and fat, respectively. From14 patients, [formula omitted]. The difference between the PERM and EVF calculated with voxel‐based T10 versus [formula omitted] ranged from 6–81% for PERM, and 2.5–23% for EVF. Conclusion. The 10–45° FAc is fast and accurately describes the known T10 of normal tissue. Voxel‐based T10 calculations are essential for correct Tofts‐based PA in heterogeneous tumors. For HN, primary and nodes [formula omitted] is a good estimate for T10 in the absence of T10 mapping capability. © 2008, American Association of Physicists in Medicine. All rights reserved.

Duke Scholars

Published In

Medical Physics

DOI

ISSN

0094-2405

Publication Date

January 1, 2008

Volume

35

Issue

6

Start / End Page

2721

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Cleland, E., Brizel, D., Yoo, D., Dolguikh, M., Muradyan, N., Barboriak, D., & Craciunescu, O. (2008). SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors. In Medical Physics (Vol. 35, p. 2721). https://doi.org/10.1118/1.2961730
Cleland, E., D. Brizel, D. Yoo, M. Dolguikh, N. Muradyan, D. Barboriak, and O. Craciunescu. “SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors.” In Medical Physics, 35:2721, 2008. https://doi.org/10.1118/1.2961730.
Cleland E, Brizel D, Yoo D, Dolguikh M, Muradyan N, Barboriak D, et al. SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors. In: Medical Physics. 2008. p. 2721.
Cleland, E., et al. “SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors.” Medical Physics, vol. 35, no. 6, 2008, p. 2721. Scopus, doi:10.1118/1.2961730.
Cleland E, Brizel D, Yoo D, Dolguikh M, Muradyan N, Barboriak D, Craciunescu O. SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors. Medical Physics. 2008. p. 2721.

Published In

Medical Physics

DOI

ISSN

0094-2405

Publication Date

January 1, 2008

Volume

35

Issue

6

Start / End Page

2721

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences