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Experimental design for high-throughput screening

Publication ,  Journal Article
Lutz, MW; Menius, JA; Choi, TD; Laskody, RG; Domanico, PL; Goetz, AS; Saussy, DL
Published in: Drug Discovery Today
January 1, 1996

Novel methods in molecular biology and advanced technologies have given pharmaceutical research laboratories the capability to test combinatorial libraries rapidly against large numbers of potential targets. Methods to identify optimal assay conditions efficiently are very useful in the development of robotic screening assays where there are numerous variables and potential interactions between the variables. This review discusses the use of statistical experimental design in the development and optimization of high-throughput screening assays. The authors provide a brief introduction to the theoretical basis for experimental design and discuss practical aspects of using these methods in a research laboratory. Two case studies demonstrate the power of the method in solving problems in assay development and illustrate the diversity of potential applications.

Duke Scholars

Published In

Drug Discovery Today

DOI

ISSN

1359-6446

Publication Date

January 1, 1996

Volume

1

Issue

7

Start / End Page

277 / 286

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
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ICMJE
MLA
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Lutz, M. W., Menius, J. A., Choi, T. D., Laskody, R. G., Domanico, P. L., Goetz, A. S., & Saussy, D. L. (1996). Experimental design for high-throughput screening. Drug Discovery Today, 1(7), 277–286. https://doi.org/10.1016/1359-6446(96)10025-8
Lutz, M. W., J. A. Menius, T. D. Choi, R. G. Laskody, P. L. Domanico, A. S. Goetz, and D. L. Saussy. “Experimental design for high-throughput screening.” Drug Discovery Today 1, no. 7 (January 1, 1996): 277–86. https://doi.org/10.1016/1359-6446(96)10025-8.
Lutz MW, Menius JA, Choi TD, Laskody RG, Domanico PL, Goetz AS, et al. Experimental design for high-throughput screening. Drug Discovery Today. 1996 Jan 1;1(7):277–86.
Lutz, M. W., et al. “Experimental design for high-throughput screening.” Drug Discovery Today, vol. 1, no. 7, Jan. 1996, pp. 277–86. Scopus, doi:10.1016/1359-6446(96)10025-8.
Lutz MW, Menius JA, Choi TD, Laskody RG, Domanico PL, Goetz AS, Saussy DL. Experimental design for high-throughput screening. Drug Discovery Today. 1996 Jan 1;1(7):277–286.
Journal cover image

Published In

Drug Discovery Today

DOI

ISSN

1359-6446

Publication Date

January 1, 1996

Volume

1

Issue

7

Start / End Page

277 / 286

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0601 Biochemistry and Cell Biology