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Vertebrate sex determination: evolutionary plasticity of a fundamental switch.

Publication ,  Journal Article
Capel, B
Published in: Nat Rev Genet
November 2017

The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex determination. More recently, advances in non-model organisms have been fuelled by the rapid evolution of affordable genome and transcriptome technologies. This Review considers the unusual plasticity in the bipotential system of sex determination and some of the diverse mechanisms that have evolved to control this critical developmental decision, including strong genetic pathways, environmental influences and epigenetic regulation. Ideas emerging from model and non-model organisms that suggest that sex determination operates as an antagonistic network with the emergent property of bistability are discussed.

Duke Scholars

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Published In

Nat Rev Genet

DOI

EISSN

1471-0064

Publication Date

November 2017

Volume

18

Issue

11

Start / End Page

675 / 689

Location

England

Related Subject Headings

  • Vertebrates
  • Sex Determination Processes
  • Models, Genetic
  • Gene Expression Profiling
  • Epigenesis, Genetic
  • Developmental Biology
  • Animals
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0607 Plant Biology
 

Citation

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Chicago
ICMJE
MLA
NLM
Capel, B. (2017). Vertebrate sex determination: evolutionary plasticity of a fundamental switch. Nat Rev Genet, 18(11), 675–689. https://doi.org/10.1038/nrg.2017.60
Capel, Blanche. “Vertebrate sex determination: evolutionary plasticity of a fundamental switch.Nat Rev Genet 18, no. 11 (November 2017): 675–89. https://doi.org/10.1038/nrg.2017.60.
Capel, Blanche. “Vertebrate sex determination: evolutionary plasticity of a fundamental switch.Nat Rev Genet, vol. 18, no. 11, Nov. 2017, pp. 675–89. Pubmed, doi:10.1038/nrg.2017.60.

Published In

Nat Rev Genet

DOI

EISSN

1471-0064

Publication Date

November 2017

Volume

18

Issue

11

Start / End Page

675 / 689

Location

England

Related Subject Headings

  • Vertebrates
  • Sex Determination Processes
  • Models, Genetic
  • Gene Expression Profiling
  • Epigenesis, Genetic
  • Developmental Biology
  • Animals
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0607 Plant Biology