Metabolomics applied to islet nutrient sensing mechanisms.
Publication
, Journal Article
Jensen, MV; Gooding, JR; Ferdaoussi, M; Dai, X-Q; Peterson, BS; MacDonald, PE; Newgard, CB
Published in: Diabetes Obes Metab
September 2017
After multiple decades of investigation, the precise mechanisms involved in fuel-stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of "metabolomics," involving mass spectrometry and nuclear magnetic resonance-based profiling of islet cells in their fuel-stimulated compared with basal states. The current article summarizes recent insights gained from application of metabolomics tools to the specific process of glucose-stimulated insulin secretion, revealing 2 new mechanisms that may provide targets for improving insulin secretion in diabetes.
Duke Scholars
Published In
Diabetes Obes Metab
DOI
EISSN
1463-1326
Publication Date
September 2017
Volume
19 Suppl 1
Issue
Suppl 1
Start / End Page
90 / 94
Location
England
Related Subject Headings
- Secretory Pathway
- Models, Biological
- Metabolomics
- Islets of Langerhans
- Insulin Secretion
- Insulin
- Humans
- Glucose
- Exocytosis
- Endocrinology & Metabolism
Citation
APA
Chicago
ICMJE
MLA
NLM
Jensen, M. V., Gooding, J. R., Ferdaoussi, M., Dai, X.-Q., Peterson, B. S., MacDonald, P. E., & Newgard, C. B. (2017). Metabolomics applied to islet nutrient sensing mechanisms. Diabetes Obes Metab, 19 Suppl 1(Suppl 1), 90–94. https://doi.org/10.1111/dom.13010
Jensen, Mette V., Jessica R. Gooding, Mourad Ferdaoussi, Xiao-Qing Dai, Brett S. Peterson, Patrick E. MacDonald, and Christopher B. Newgard. “Metabolomics applied to islet nutrient sensing mechanisms.” Diabetes Obes Metab 19 Suppl 1, no. Suppl 1 (September 2017): 90–94. https://doi.org/10.1111/dom.13010.
Jensen MV, Gooding JR, Ferdaoussi M, Dai X-Q, Peterson BS, MacDonald PE, et al. Metabolomics applied to islet nutrient sensing mechanisms. Diabetes Obes Metab. 2017 Sep;19 Suppl 1(Suppl 1):90–4.
Jensen, Mette V., et al. “Metabolomics applied to islet nutrient sensing mechanisms.” Diabetes Obes Metab, vol. 19 Suppl 1, no. Suppl 1, Sept. 2017, pp. 90–94. Pubmed, doi:10.1111/dom.13010.
Jensen MV, Gooding JR, Ferdaoussi M, Dai X-Q, Peterson BS, MacDonald PE, Newgard CB. Metabolomics applied to islet nutrient sensing mechanisms. Diabetes Obes Metab. 2017 Sep;19 Suppl 1(Suppl 1):90–94.
Published In
Diabetes Obes Metab
DOI
EISSN
1463-1326
Publication Date
September 2017
Volume
19 Suppl 1
Issue
Suppl 1
Start / End Page
90 / 94
Location
England
Related Subject Headings
- Secretory Pathway
- Models, Biological
- Metabolomics
- Islets of Langerhans
- Insulin Secretion
- Insulin
- Humans
- Glucose
- Exocytosis
- Endocrinology & Metabolism