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Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models.

Publication ,  Journal Article
Davey, SK; Aung, A; Agrawal, G; Lim, HL; Kar, M; Varghese, S
Published in: Tissue Eng Part C Methods
November 2015

Techniques that can create three-dimensional (3D) structures to provide architectural support for cells have a significant impact in generating complex and hierarchically organized tissues/organs. In recent times, a number of technologies, including photopatterning, have been developed to create such intricate 3D structures. In this study, we describe an easy-to-implement photopatterning approach, involving a conventional fluorescent microscope and a simple photomask, to encapsulate cells within spatially defined 3D structures. We have demonstrated the ease and the versatility of this approach by creating simple to complex as well as multilayered structures. We have extended this photopatterning approach to incorporate and spatially organize multiple cell types, thereby establishing coculture systems. Such cost-effective and easy-to-use approaches can greatly advance tissue engineering strategies.

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Published In

Tissue Eng Part C Methods

DOI

EISSN

1937-3392

Publication Date

November 2015

Volume

21

Issue

11

Start / End Page

1188 / 1196

Location

United States

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Light
  • Imaging, Three-Dimensional
  • Hydrogels
  • Humans
  • Disease Models, Animal
  • Cells, Immobilized
  • Cell Line, Tumor
  • Cattle
 

Citation

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Davey, S. K., Aung, A., Agrawal, G., Lim, H. L., Kar, M., & Varghese, S. (2015). Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models. Tissue Eng Part C Methods, 21(11), 1188–1196. https://doi.org/10.1089/ten.TEC.2015.0179
Davey, Shruti Krishna, Aereas Aung, Gaurav Agrawal, Han Liang Lim, Mrityunjoy Kar, and Shyni Varghese. “Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models.Tissue Eng Part C Methods 21, no. 11 (November 2015): 1188–96. https://doi.org/10.1089/ten.TEC.2015.0179.
Davey SK, Aung A, Agrawal G, Lim HL, Kar M, Varghese S. Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models. Tissue Eng Part C Methods. 2015 Nov;21(11):1188–96.
Davey, Shruti Krishna, et al. “Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models.Tissue Eng Part C Methods, vol. 21, no. 11, Nov. 2015, pp. 1188–96. Pubmed, doi:10.1089/ten.TEC.2015.0179.
Davey SK, Aung A, Agrawal G, Lim HL, Kar M, Varghese S. Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models. Tissue Eng Part C Methods. 2015 Nov;21(11):1188–1196.

Published In

Tissue Eng Part C Methods

DOI

EISSN

1937-3392

Publication Date

November 2015

Volume

21

Issue

11

Start / End Page

1188 / 1196

Location

United States

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Light
  • Imaging, Three-Dimensional
  • Hydrogels
  • Humans
  • Disease Models, Animal
  • Cells, Immobilized
  • Cell Line, Tumor
  • Cattle