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A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial.

Publication ,  Journal Article
Hughes, BL; Gans, KM; Raker, C; Hipolito, ER; Rouse, DJ
Published in: Obstet Gynecol
October 2017

OBJECTIVE: To estimate the effects of a brief prenatal behavioral intervention on risk behaviors for maternal cytomegalovirus (CMV) infection. METHODS: Women were screened with CMV serology during prenatal care before 20 weeks of gestation and followed for at least 10 weeks. Women without serologic evidence of primary CMV infection were approached. Participants were apprised of serostatus and then randomized 2:1 to either a brief behavioral intervention during their prenatal care visit or to standard care (a brochure). The 7- to 10-minute in-office intervention included a video and hygiene education using motivational interviewing. Participants were then given a reminder calendar to take home and weekly text message reminders. The primary outcome was change in behavioral compliance score on a scale of 0-100. Secondary outcomes included process evaluation and domains of behavior change. A sample size of 180 participants was planned to compare the behavioral compliance score change of at least 15% between intervention and control groups with 80% power and 2.5% two-sided α. RESULTS: From April 2013 to October 2014, 197 women were randomized. One hundred eighty-seven (96%) had outcome data available. Mean gestational age at screening and randomization was 9 4/7 and 13 6/7 weeks of gestation, respectively. Primary outcome assessment occurred at a mean of 28 4/7 weeks of gestation. Baseline behavioral compliance scores increased modestly in the intervention group (mean: 7-point increase from 80.7 to 87.7, 95% CI 2.4-5.9) compared with the comparison group (mean: 4-point increase from 79.7 to 84.1, 95% CI 5.9-8.4; mean difference in change score: 3.0, 95% CI, 0.8-5.2; P=.007). Those in the intervention group reported change in risk perception related to perceived severity and susceptibility, self-efficacy, and perceived norms (P<.05 for all). CONCLUSION: A brief behavioral intervention delivered in the prenatal care setting was modestly effective at changing behaviors related to CMV infection risk. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT01819519.

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Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

October 2017

Volume

130

Issue

4

Start / End Page

726 / 734

Location

United States

Related Subject Headings

  • Text Messaging
  • Single-Blind Method
  • Risk-Taking
  • Risk Factors
  • Prenatal Care
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Outcome Assessment, Health Care
  • Obstetrics & Reproductive Medicine
  • Motivational Interviewing
 

Citation

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Hughes, B. L., Gans, K. M., Raker, C., Hipolito, E. R., & Rouse, D. J. (2017). A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial. Obstet Gynecol, 130(4), 726–734. https://doi.org/10.1097/AOG.0000000000002216
Hughes, Brenna L., Kim M. Gans, Christina Raker, Evelyn R. Hipolito, and Dwight J. Rouse. “A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial.Obstet Gynecol 130, no. 4 (October 2017): 726–34. https://doi.org/10.1097/AOG.0000000000002216.
Hughes BL, Gans KM, Raker C, Hipolito ER, Rouse DJ. A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial. Obstet Gynecol. 2017 Oct;130(4):726–34.
Hughes, Brenna L., et al. “A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial.Obstet Gynecol, vol. 130, no. 4, Oct. 2017, pp. 726–34. Pubmed, doi:10.1097/AOG.0000000000002216.
Hughes BL, Gans KM, Raker C, Hipolito ER, Rouse DJ. A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial. Obstet Gynecol. 2017 Oct;130(4):726–734.

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

October 2017

Volume

130

Issue

4

Start / End Page

726 / 734

Location

United States

Related Subject Headings

  • Text Messaging
  • Single-Blind Method
  • Risk-Taking
  • Risk Factors
  • Prenatal Care
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Outcome Assessment, Health Care
  • Obstetrics & Reproductive Medicine
  • Motivational Interviewing