Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood.
Publication
, Journal Article
Jones, AD; Dunlap, MR; Gospe, SM
Published in: J Anal Toxicol
September 1994
An accurate and sensitive yet simple protocol for the analysis of toluene in submilliliter quantities of whole blood using stable-isotope dilution GC-MS has been developed and evaluated for use in pharmacokinetic studies of toluene exposure. The method involves the use of toluene-d8, a relatively inexpensive chemical used as a solvent for nuclear magnetic resonance spectroscopy, as an internal standard and extraction with pentane. This procedure allows for the determination of toluene in whole blood down to approximately 5 ng/mL and is suitable for pharmacokinetic measurements and biomonitoring of exposure to toluene.
Duke Scholars
Published In
J Anal Toxicol
DOI
ISSN
0146-4760
Publication Date
September 1994
Volume
18
Issue
5
Start / End Page
251 / 254
Location
England
Related Subject Headings
- Toluene
- Rats, Sprague-Dawley
- Rats, Inbred F344
- Rats
- Pregnancy
- Male
- Isotopes
- Indicator Dilution Techniques
- Gas Chromatography-Mass Spectrometry
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Jones, A. D., Dunlap, M. R., & Gospe, S. M. (1994). Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood. J Anal Toxicol, 18(5), 251–254. https://doi.org/10.1093/jat/18.5.251
Jones, A. D., M. R. Dunlap, and S. M. Gospe. “Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood.” J Anal Toxicol 18, no. 5 (September 1994): 251–54. https://doi.org/10.1093/jat/18.5.251.
Jones AD, Dunlap MR, Gospe SM. Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood. J Anal Toxicol. 1994 Sep;18(5):251–4.
Jones, A. D., et al. “Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood.” J Anal Toxicol, vol. 18, no. 5, Sept. 1994, pp. 251–54. Pubmed, doi:10.1093/jat/18.5.251.
Jones AD, Dunlap MR, Gospe SM. Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood. J Anal Toxicol. 1994 Sep;18(5):251–254.
Published In
J Anal Toxicol
DOI
ISSN
0146-4760
Publication Date
September 1994
Volume
18
Issue
5
Start / End Page
251 / 254
Location
England
Related Subject Headings
- Toluene
- Rats, Sprague-Dawley
- Rats, Inbred F344
- Rats
- Pregnancy
- Male
- Isotopes
- Indicator Dilution Techniques
- Gas Chromatography-Mass Spectrometry
- Female