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Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty.

Publication ,  Journal Article
Hobbs, JC; Welsby, IJ; Green, CL; Dhakal, IB; Wellman, SS
Published in: J Arthroplasty
January 2018

BACKGROUND: Total hip and knee arthroplasty (THA and TKA) are associated with significant blood loss and some patients require postoperative blood transfusion. While tranexamic acid has been studied extensively among this population, we tested the hypothesis that epsilon aminocaproic acid (EACA) can reduce blood loss and transfusion after joint arthroplasty. METHODS: In April 2014, our Veterans Affairs Medical Center introduced a protocol to administer EACA during THA and TKA. No antifibrinolytics were used previously. We retrospectively compared blood loss and incidence of transfusion among patients who underwent primary arthroplasty in the year before standardized administration of EACA with patients having the same procedures the following year. Blood loss was measured as delta hemoglobin (preoperative hemoglobin - hemoglobin on postoperative day 1). All patients undergoing primary THA or TKA were included. Patients having revision surgery were excluded. RESULTS: We identified 185 primary arthroplasty patients from the year before and 184 from the year after introducing the EACA protocol. There were no changes in surgical technique or attending surgeons during this period. Delta hemoglobin was significantly lower in the EACA group (2.7 ± 0.8 mg/dL) compared to the control group (3.4 ± 1.1 mg/dL) (P < .0001). The incidence of blood transfusion was also significantly lower in the EACA group (2.7%) compared to the control group (25.4%) (P < .0001). There was no difference in venous thromboembolic complications between groups. CONCLUSION: We demonstrated reductions in hemoglobin loss and transfusion following introduction of the EACA protocol in patients undergoing primary arthroplasty. EACA offers a lower cost alternative to TXA for reducing blood loss and transfusion in this population.

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Published In

J Arthroplasty

DOI

EISSN

1532-8406

Publication Date

January 2018

Volume

33

Issue

1

Start / End Page

55 / 60

Location

United States

Related Subject Headings

  • Tranexamic Acid
  • Retrospective Studies
  • Postoperative Period
  • Postoperative Hemorrhage
  • Orthopedics
  • Middle Aged
  • Male
  • Humans
  • Hemoglobins
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hobbs, J. C., Welsby, I. J., Green, C. L., Dhakal, I. B., & Wellman, S. S. (2018). Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty. J Arthroplasty, 33(1), 55–60. https://doi.org/10.1016/j.arth.2017.08.020
Hobbs, Juliann C., Ian J. Welsby, Cynthia L. Green, Ishwori B. Dhakal, and Samuel S. Wellman. “Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty.J Arthroplasty 33, no. 1 (January 2018): 55–60. https://doi.org/10.1016/j.arth.2017.08.020.
Hobbs JC, Welsby IJ, Green CL, Dhakal IB, Wellman SS. Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty. J Arthroplasty. 2018 Jan;33(1):55–60.
Hobbs, Juliann C., et al. “Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty.J Arthroplasty, vol. 33, no. 1, Jan. 2018, pp. 55–60. Pubmed, doi:10.1016/j.arth.2017.08.020.
Hobbs JC, Welsby IJ, Green CL, Dhakal IB, Wellman SS. Epsilon Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Hip and Total Knee Arthroplasty. J Arthroplasty. 2018 Jan;33(1):55–60.
Journal cover image

Published In

J Arthroplasty

DOI

EISSN

1532-8406

Publication Date

January 2018

Volume

33

Issue

1

Start / End Page

55 / 60

Location

United States

Related Subject Headings

  • Tranexamic Acid
  • Retrospective Studies
  • Postoperative Period
  • Postoperative Hemorrhage
  • Orthopedics
  • Middle Aged
  • Male
  • Humans
  • Hemoglobins
  • Female