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Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

Publication ,  Journal Article
Ng, MCY; Shriner, D; Chen, BH; Li, J; Chen, W-M; Guo, X; Liu, J; Bielinski, SJ; Yanek, LR; Nalls, MA; Comeau, ME; Rasmussen-Torvik, LJ; An, P ...
Published in: PLoS Genet
August 2014

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)

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Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

August 2014

Volume

10

Issue

8

Start / End Page

e1004517

Location

United States

Related Subject Headings

  • Transcription Factor 7-Like 2 Protein
  • Polymorphism, Single Nucleotide
  • Mutant Chimeric Proteins
  • KCNQ1 Potassium Channel
  • Humans
  • HMGA2 Protein
  • HLA-B27 Antigen
  • Genome-Wide Association Study
  • Diabetes Mellitus, Type 2
  • Developmental Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W.-M., Guo, X., … MEta-analysis of type 2 DIabetes in African Americans Consortium, . (2014). Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet, 10(8), e1004517. https://doi.org/10.1371/journal.pgen.1004517
Ng, Maggie C. Y., Daniel Shriner, Brian H. Chen, Jiang Li, Wei-Min Chen, Xiuqing Guo, Jiankang Liu, et al. “Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.PLoS Genet 10, no. 8 (August 2014): e1004517. https://doi.org/10.1371/journal.pgen.1004517.
Ng MCY, Shriner D, Chen BH, Li J, Chen W-M, Guo X, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014 Aug;10(8):e1004517.
Ng, Maggie C. Y., et al. “Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.PLoS Genet, vol. 10, no. 8, Aug. 2014, p. e1004517. Pubmed, doi:10.1371/journal.pgen.1004517.
Ng MCY, Shriner D, Chen BH, Li J, Chen W-M, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively BM, Palmer ND, Mudgal P, Langefeld CD, Keene KL, Freedman BI, Mychaleckyj JC, Nayak U, Raffel LJ, Goodarzi MO, Chen Y-DI, Taylor HA, Correa A, Sims M, Couper D, Pankow JS, Boerwinkle E, Adeyemo A, Doumatey A, Chen G, Mathias RA, Vaidya D, Singleton AB, Zonderman AB, Igo RP, Sedor JR, FIND Consortium, Kabagambe EK, Siscovick DS, McKnight B, Rice K, Liu Y, Hsueh W-C, Zhao W, Bielak LF, Kraja A, Province MA, Bottinger EP, Gottesman O, Cai Q, Zheng W, Blot WJ, Lowe WL, Pacheco JA, Crawford DC, eMERGE Consortium, DIAGRAM Consortium, Grundberg E, MuTHER Consortium, Rich SS, Hayes MG, Shu X-O, Loos RJF, Borecki IB, Peyser PA, Cummings SR, Psaty BM, Fornage M, Iyengar SK, Evans MK, Becker DM, Kao WHL, Wilson JG, Rotter JI, Sale MM, Liu S, Rotimi CN, Bowden DW, MEta-analysis of type 2 DIabetes in African Americans Consortium. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014 Aug;10(8):e1004517.

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

August 2014

Volume

10

Issue

8

Start / End Page

e1004517

Location

United States

Related Subject Headings

  • Transcription Factor 7-Like 2 Protein
  • Polymorphism, Single Nucleotide
  • Mutant Chimeric Proteins
  • KCNQ1 Potassium Channel
  • Humans
  • HMGA2 Protein
  • HLA-B27 Antigen
  • Genome-Wide Association Study
  • Diabetes Mellitus, Type 2
  • Developmental Biology