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Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.

Publication ,  Journal Article
Reddy, A; Zhang, J; Davis, NS; Moffitt, AB; Love, CL; Waldrop, A; Leppa, S; Pasanen, A; Meriranta, L; Karjalainen-Lindsberg, M-L; Nørgaard, P ...
Published in: Cell
October 5, 2017

Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and its response to therapy. Here, we performed an integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of 1,001 DLBCL patients to comprehensively define the landscape of 150 genetic drivers of the disease. We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote cell growth. A prognostic model comprising these genetic alterations outperformed current established methods: cell of origin, the International Prognostic Index comprising clinical variables, and dual MYC and BCL2 expression. These results comprehensively define the genetic drivers and their functional roles in DLBCL to identify new therapeutic opportunities in the disease.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

October 5, 2017

Volume

171

Issue

2

Start / End Page

481 / 494.e15

Location

United States

Related Subject Headings

  • Rituximab
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Humans
  • Gene Expression Profiling
  • Female
  • Exome
  • Developmental Biology
  • Cells, Cultured
  • Cell Line, Tumor
 

Citation

APA
Chicago
ICMJE
MLA
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Reddy, A., Zhang, J., Davis, N. S., Moffitt, A. B., Love, C. L., Waldrop, A., … Dave, S. S. (2017). Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell, 171(2), 481-494.e15. https://doi.org/10.1016/j.cell.2017.09.027
Reddy, Anupama, Jenny Zhang, Nicholas S. Davis, Andrea B. Moffitt, Cassandra L. Love, Alexander Waldrop, Sirpa Leppa, et al. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.Cell 171, no. 2 (October 5, 2017): 481-494.e15. https://doi.org/10.1016/j.cell.2017.09.027.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, et al. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct 5;171(2):481-494.e15.
Reddy, Anupama, et al. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.Cell, vol. 171, no. 2, Oct. 2017, pp. 481-494.e15. Pubmed, doi:10.1016/j.cell.2017.09.027.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg M-L, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong Y-L, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct 5;171(2):481-494.e15.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

October 5, 2017

Volume

171

Issue

2

Start / End Page

481 / 494.e15

Location

United States

Related Subject Headings

  • Rituximab
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Humans
  • Gene Expression Profiling
  • Female
  • Exome
  • Developmental Biology
  • Cells, Cultured
  • Cell Line, Tumor