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Emerging Therapies for Congestive Heart Failure.

Publication ,  Journal Article
Povsic, TJ
Published in: Clin Pharmacol Ther
January 2018

The treatment of atherosclerotic heart disease has improved remarkably over the last several decades; however, the outlook for patients with symptomatic congestive heart failure with reduced ejection fraction remains bleak. Current drug therapies target the neurohormonal activation that accompanies congestive heart failure, but do not address the fundamental pathology inherent in this condition-the loss of contractile capacity. Stem cell therapies offer the possibility of rectifying this deficiency and normalizing left ventricular dimensions and cardiac performance by regenerating novel contractile tissue, thereby reversing the negative remodeling that portends progressive left ventricular dysfunction, worsening symptoms, and ultimately cardiogenic shock. Here we review the promise of stem cell therapies in the treatment of heart failure with reduced ejection fraction, the current state of clinical developments, and briefly comment on the future of the field.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

January 2018

Volume

103

Issue

1

Start / End Page

77 / 87

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Stem Cell Transplantation
  • Pharmacology & Pharmacy
  • Myocardial Contraction
  • Humans
  • Heart Failure
  • Disease Progression
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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MLA
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Povsic, T. J. (2018). Emerging Therapies for Congestive Heart Failure. Clin Pharmacol Ther, 103(1), 77–87. https://doi.org/10.1002/cpt.913
Povsic, Thomas J. “Emerging Therapies for Congestive Heart Failure.Clin Pharmacol Ther 103, no. 1 (January 2018): 77–87. https://doi.org/10.1002/cpt.913.
Povsic TJ. Emerging Therapies for Congestive Heart Failure. Clin Pharmacol Ther. 2018 Jan;103(1):77–87.
Povsic, Thomas J. “Emerging Therapies for Congestive Heart Failure.Clin Pharmacol Ther, vol. 103, no. 1, Jan. 2018, pp. 77–87. Pubmed, doi:10.1002/cpt.913.
Povsic TJ. Emerging Therapies for Congestive Heart Failure. Clin Pharmacol Ther. 2018 Jan;103(1):77–87.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

January 2018

Volume

103

Issue

1

Start / End Page

77 / 87

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Stem Cell Transplantation
  • Pharmacology & Pharmacy
  • Myocardial Contraction
  • Humans
  • Heart Failure
  • Disease Progression
  • 3214 Pharmacology and pharmaceutical sciences