Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.
Publication
, Journal Article
Yan, S-L; Li, Y-H; Chen, X-Q; Liu, D; Chen, C-H; Li, R-T
Published in: Phytochemistry
January 2018
Six previously undescribed diterpenoids, named euphorantins S-T and euphorneroids A-D, including ingol and ent-atisane types, along with eleven known diterpenoids, were isolated from Euphorbia neriifolia. Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Euphorneroid D and ent-3-oxoatisan-16α,17-acetonide exhibited moderate anti-HIV-1 activities, with EC50 values of 34 μM (SI = 2.3) and 24 μM (SI = 1.9), respectively.
Duke Scholars
Published In
Phytochemistry
DOI
EISSN
1873-3700
Publication Date
January 2018
Volume
145
Start / End Page
40 / 47
Location
England
Related Subject Headings
- Structure-Activity Relationship
- Plant Stems
- Plant Biology & Botany
- Plant Bark
- Molecular Structure
- Microbial Sensitivity Tests
- Humans
- HIV-1
- Euphorbia
- Dose-Response Relationship, Drug
Citation
APA
Chicago
ICMJE
MLA
NLM
Yan, S.-L., Li, Y.-H., Chen, X.-Q., Liu, D., Chen, C.-H., & Li, R.-T. (2018). Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity. Phytochemistry, 145, 40–47. https://doi.org/10.1016/j.phytochem.2017.10.006
Yan, Shi-Li, Yan-Hong Li, Xuan-Qin Chen, Dan Liu, Chin-Ho Chen, and Rong-Tao Li. “Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.” Phytochemistry 145 (January 2018): 40–47. https://doi.org/10.1016/j.phytochem.2017.10.006.
Yan S-L, Li Y-H, Chen X-Q, Liu D, Chen C-H, Li R-T. Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity. Phytochemistry. 2018 Jan;145:40–7.
Yan, Shi-Li, et al. “Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.” Phytochemistry, vol. 145, Jan. 2018, pp. 40–47. Pubmed, doi:10.1016/j.phytochem.2017.10.006.
Yan S-L, Li Y-H, Chen X-Q, Liu D, Chen C-H, Li R-T. Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity. Phytochemistry. 2018 Jan;145:40–47.
Published In
Phytochemistry
DOI
EISSN
1873-3700
Publication Date
January 2018
Volume
145
Start / End Page
40 / 47
Location
England
Related Subject Headings
- Structure-Activity Relationship
- Plant Stems
- Plant Biology & Botany
- Plant Bark
- Molecular Structure
- Microbial Sensitivity Tests
- Humans
- HIV-1
- Euphorbia
- Dose-Response Relationship, Drug