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Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial.

Publication ,  Journal Article
Chatterjee, R; Slentz, C; Davenport, CA; Johnson, J; Lin, P-H; Muehlbauer, M; D'Alessio, D; Svetkey, LP; Edelman, D
Published in: Am J Clin Nutr
December 2017

Background: Low potassium has been identified both as a risk factor for type 2 diabetes and as a mediator of the racial disparity in diabetes risk. Low potassium could be a potentially modifiable risk factor, particularly for African Americans.Objective: We sought to determine the effects of potassium chloride (KCl) supplements, at a commonly prescribed dose, on measures of potassium and glucose metabolism.Design: Among African-American adults with prediabetes, we conducted a double-blinded pilot randomized controlled trial that compared the effects of 40 mEq K/d as KCl supplements with a matching placebo, taken for 3 mo, on measures of potassium and glucose metabolism, with measures collected from frequently sampled oral-glucose-tolerance tests (OGTTs).Results: Twenty-seven of 29 recruited participants completed the trial. Participants had high adherence to the study medication (92% by pill count). Participants in both groups gained weight, with an overall mean ± SD weight gain of 1.24 ± 2.03 kg. In comparison with participants who received placebo, urine potassium but not serum potassium increased significantly among participants randomly assigned to receive KCl (P = 0.005 and 0.258, respectively). At the end of the study, participants taking KCl had stable or improved fasting glucose, with a mean ± SD change in fasting glucose of -1.1 ± 8.4 mg/dL compared with an increase of 6.1 ± 7.6 mg/dL in those who received placebo (P = 0.03 for comparison between arms). There were no significant differences in glucose or insulin measures during the OGTT between the 2 groups, but there was a trend for improved insulin sensitivity in potassium-treated participants.Conclusions: In this pilot trial, KCl at a dose of 40 mEq/d did not increase serum potassium significantly. However, despite weight gain, KCl prevented worsening of fasting glucose. Further studies in larger sample sizes, as well as with interventions to increase serum potassium more than was achieved with our intervention, are indicated to definitively test this potentially safe and inexpensive approach to reducing diabetes risk. This trial was registered at clinicaltrials.gov as NCT02236598.

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Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

December 2017

Volume

106

Issue

6

Start / End Page

1431 / 1438

Location

United States

Related Subject Headings

  • Weight Gain
  • Risk Factors
  • Prediabetic State
  • Potassium Deficiency
  • Potassium Chloride
  • Potassium
  • Pilot Projects
  • Nutrition & Dietetics
  • Middle Aged
  • Male
 

Citation

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ICMJE
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Chatterjee, R., Slentz, C., Davenport, C. A., Johnson, J., Lin, P.-H., Muehlbauer, M., … Edelman, D. (2017). Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial. Am J Clin Nutr, 106(6), 1431–1438. https://doi.org/10.3945/ajcn.117.161570
Chatterjee, Ranee, Cris Slentz, Clemontina A. Davenport, Johanna Johnson, Pao-Hwa Lin, Michael Muehlbauer, David D’Alessio, Laura P. Svetkey, and David Edelman. “Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial.Am J Clin Nutr 106, no. 6 (December 2017): 1431–38. https://doi.org/10.3945/ajcn.117.161570.
Chatterjee R, Slentz C, Davenport CA, Johnson J, Lin P-H, Muehlbauer M, et al. Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial. Am J Clin Nutr. 2017 Dec;106(6):1431–8.
Chatterjee, Ranee, et al. “Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial.Am J Clin Nutr, vol. 106, no. 6, Dec. 2017, pp. 1431–38. Pubmed, doi:10.3945/ajcn.117.161570.
Chatterjee R, Slentz C, Davenport CA, Johnson J, Lin P-H, Muehlbauer M, D’Alessio D, Svetkey LP, Edelman D. Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial. Am J Clin Nutr. 2017 Dec;106(6):1431–1438.
Journal cover image

Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

December 2017

Volume

106

Issue

6

Start / End Page

1431 / 1438

Location

United States

Related Subject Headings

  • Weight Gain
  • Risk Factors
  • Prediabetic State
  • Potassium Deficiency
  • Potassium Chloride
  • Potassium
  • Pilot Projects
  • Nutrition & Dietetics
  • Middle Aged
  • Male