Skip to main content

Stimulation of the sensory pudendal nerve increases bladder capacity in the rat.

Publication ,  Journal Article
Hokanson, JA; Langdale, CL; Sridhar, A; Grill, WM
Published in: American journal of physiology. Renal physiology
April 2018

Pudendal nerve stimulation is a promising treatment approach for lower urinary tract dysfunction, including symptoms of overactive bladder. Despite some promising clinical studies, there remain many unknowns as to how best to stimulate the pudendal nerve to maximize therapeutic efficacy. We quantified changes in bladder capacity and voiding efficiency during single-fill cystometry in response to electrical stimulation of the sensory branch of the pudendal nerve in urethane-anesthetized female Wistar rats. Increases in bladder capacity were dependent on both stimulation amplitude and rate. Stimulation that produced increases in bladder capacity also led to reductions in voiding efficiency. Also, there was a stimulation carryover effect, and increases in bladder capacity persisted during several nonstimulated trials following stimulated trials. Intravesically administered PGE2 reduced bladder capacity, producing a model of overactive bladder (OAB), and sensory pudendal nerve stimulation again increased bladder capacity but also reduced voiding efficiency. This study serves as a basis for future studies that seek to maximize the therapeutic efficacy of sensory pudendal nerve stimulation for the symptoms of OAB.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

American journal of physiology. Renal physiology

DOI

EISSN

1522-1466

ISSN

1931-857X

Publication Date

April 2018

Volume

314

Issue

4

Start / End Page

F543 / F550

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urinary Bladder, Overactive
  • Urinary Bladder
  • Rats, Wistar
  • Pudendal Nerve
  • Female
  • Electric Stimulation Therapy
  • Disease Models, Animal
  • Dinoprostone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hokanson, J. A., Langdale, C. L., Sridhar, A., & Grill, W. M. (2018). Stimulation of the sensory pudendal nerve increases bladder capacity in the rat. American Journal of Physiology. Renal Physiology, 314(4), F543–F550. https://doi.org/10.1152/ajprenal.00373.2017
Hokanson, James A., Christopher L. Langdale, Arun Sridhar, and Warren M. Grill. “Stimulation of the sensory pudendal nerve increases bladder capacity in the rat.American Journal of Physiology. Renal Physiology 314, no. 4 (April 2018): F543–50. https://doi.org/10.1152/ajprenal.00373.2017.
Hokanson JA, Langdale CL, Sridhar A, Grill WM. Stimulation of the sensory pudendal nerve increases bladder capacity in the rat. American journal of physiology Renal physiology. 2018 Apr;314(4):F543–50.
Hokanson, James A., et al. “Stimulation of the sensory pudendal nerve increases bladder capacity in the rat.American Journal of Physiology. Renal Physiology, vol. 314, no. 4, Apr. 2018, pp. F543–50. Epmc, doi:10.1152/ajprenal.00373.2017.
Hokanson JA, Langdale CL, Sridhar A, Grill WM. Stimulation of the sensory pudendal nerve increases bladder capacity in the rat. American journal of physiology Renal physiology. 2018 Apr;314(4):F543–F550.

Published In

American journal of physiology. Renal physiology

DOI

EISSN

1522-1466

ISSN

1931-857X

Publication Date

April 2018

Volume

314

Issue

4

Start / End Page

F543 / F550

Related Subject Headings

  • Urology & Nephrology
  • Urodynamics
  • Urinary Bladder, Overactive
  • Urinary Bladder
  • Rats, Wistar
  • Pudendal Nerve
  • Female
  • Electric Stimulation Therapy
  • Disease Models, Animal
  • Dinoprostone