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Salt, Hypertension, and Immunity.

Publication ,  Journal Article
Rucker, AJ; Rudemiller, NP; Crowley, SD
Published in: Annu Rev Physiol
February 10, 2018

The link between inappropriate salt retention in the kidney and hypertension is well recognized. However, growing evidence suggests that the immune system can play surprising roles in sodium homeostasis, such that the study of inflammatory cells and their secreted effectors has provided important insights into salt sensitivity. As part of the innate immune system, myeloid cells have diverse roles in blood pressure regulation, ranging from prohypertensive actions in the kidney, vasculature, and brain, to effects in the skin that attenuate blood pressure elevation. In parallel, T lymphocyte subsets, as key constituents of the adaptive immune compartment, have variable effects on renal sodium handling and the hypertensive response, accruing from the functions of the cytokines that they produce. Conversely, salt can directly modulate the phenotypes of myeloid and T cells, illustrating bidirectional regulatory mechanisms through which sodium and the immune system coordinately impact blood pressure. This review details the complex interplay between myeloid cells, T cells, and salt in the pathogenesis of essential hypertension.

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Published In

Annu Rev Physiol

DOI

EISSN

1545-1585

Publication Date

February 10, 2018

Volume

80

Start / End Page

283 / 307

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Sodium Chloride
  • Physiology
  • Monocytes
  • Kidney
  • Hypertension
  • Humans
  • Cytokines
  • Blood Pressure
  • Animals
 

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Rucker, A. J., Rudemiller, N. P., & Crowley, S. D. (2018). Salt, Hypertension, and Immunity. Annu Rev Physiol, 80, 283–307. https://doi.org/10.1146/annurev-physiol-021317-121134
Rucker, A Justin, Nathan P. Rudemiller, and Steven D. Crowley. “Salt, Hypertension, and Immunity.Annu Rev Physiol 80 (February 10, 2018): 283–307. https://doi.org/10.1146/annurev-physiol-021317-121134.
Rucker AJ, Rudemiller NP, Crowley SD. Salt, Hypertension, and Immunity. Annu Rev Physiol. 2018 Feb 10;80:283–307.
Rucker, A. Justin, et al. “Salt, Hypertension, and Immunity.Annu Rev Physiol, vol. 80, Feb. 2018, pp. 283–307. Pubmed, doi:10.1146/annurev-physiol-021317-121134.
Rucker AJ, Rudemiller NP, Crowley SD. Salt, Hypertension, and Immunity. Annu Rev Physiol. 2018 Feb 10;80:283–307.

Published In

Annu Rev Physiol

DOI

EISSN

1545-1585

Publication Date

February 10, 2018

Volume

80

Start / End Page

283 / 307

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Sodium Chloride
  • Physiology
  • Monocytes
  • Kidney
  • Hypertension
  • Humans
  • Cytokines
  • Blood Pressure
  • Animals