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Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease.

Publication ,  Journal Article
Perito, ER; Ajmera, V; Bass, NM; Rosenthal, P; Lavine, JE; Schwimmer, JB; Yates, KP; Diehl, AM; Molleston, JP; Murray, KF; Scheimann, A ...
Published in: Hepatol Commun
September 2017

BACKGROUND: Reliable non-invasive markers to characterize inflammation, hepatocellular ballooning, and fibrosis in nonalcoholic fatty liver disease (NAFLD) are lacking. We investigated the relationship between plasma cytokine levels and features of NAFLD histology to gain insight into cellular pathways driving NASH and to identify potential non-invasive discriminators of NAFLD severity and pattern. METHODS: Cytokines were measured from plasma obtained at enrollment in pediatric participants in NASH Clinical Research Network studies with liver biopsy-proven NAFLD. Cytokines were chosen a priori as possible discriminators of NASH and its components. Minimization of Akaike Information Criterion (AIC) was used to determine cytokines retained in multivariable models. RESULTS: Of 235 subjects, 31% had "Definite NASH" on liver histology, 43% had "Borderline NASH", and 25% had NAFLD but not NASH. Total plasminogen activator inhibitor 1 (PAI1) and activated PAI1 levels were higher in pediatric participants with Definite NASH and with lobular inflammation. Interleukin-8 (IL-8) was higher in those with stage 3-4 fibrosis and lobular inflammation. sIL-2rα was higher in children with stage 3-4 fibrosis and portal inflammation. In multivariable analysis, PAI1 variables were discriminators of Borderline/Definite NASH, definite NASH, lobular inflammation and ballooning. IL-8 increased with steatosis and fibrosis severity; sIL-2rα increased with fibrosis severity and portal inflammation. IL-7 decreased with portal inflammation and fibrosis severity. CONCLUSIONS: Plasma cytokines associated with histology varied considerably among NASH features, suggesting promising avenues for investigation. Future, more targeted analysis is needed to identify the role of these markers in NAFLD and to evaluate their potential as non-invasive discriminators of disease severity.

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Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

September 2017

Volume

1

Issue

7

Start / End Page

609 / 622

Location

United States

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Perito, E. R., Ajmera, V., Bass, N. M., Rosenthal, P., Lavine, J. E., Schwimmer, J. B., … Aouizerat, B. (2017). Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun, 1(7), 609–622. https://doi.org/10.1002/hep4.1068
Perito, Emily R., Veeral Ajmera, Nathan M. Bass, Philip Rosenthal, Joel E. Lavine, Jeffrey B. Schwimmer, Katherine P. Yates, et al. “Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease.Hepatol Commun 1, no. 7 (September 2017): 609–22. https://doi.org/10.1002/hep4.1068.
Perito ER, Ajmera V, Bass NM, Rosenthal P, Lavine JE, Schwimmer JB, et al. Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2017 Sep;1(7):609–22.
Perito, Emily R., et al. “Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease.Hepatol Commun, vol. 1, no. 7, Sept. 2017, pp. 609–22. Pubmed, doi:10.1002/hep4.1068.
Perito ER, Ajmera V, Bass NM, Rosenthal P, Lavine JE, Schwimmer JB, Yates KP, Diehl AM, Molleston JP, Murray KF, Scheimann A, Gill R, Glidden D, Aouizerat B. Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2017 Sep;1(7):609–622.

Published In

Hepatol Commun

DOI

EISSN

2471-254X

Publication Date

September 2017

Volume

1

Issue

7

Start / End Page

609 / 622

Location

United States

Related Subject Headings

  • 3202 Clinical sciences