Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
Publication
, Journal Article
Thérien, M; Brideau, C; Chan, CC; Cromlish, WA; Gauthier, JY; Gordon, R; Greig, G; Kargman, S; Lau, CK; Leblanc, Y; Li, CS; O'Neill, GP ...
Published in: Bioorganic and Medicinal Chemistry Letters
January 7, 1997
A series of 5,6-diarylimidazo[2.1-b]thiazole compounds were prepared and their inhibitory potencies against COX-2 and Cox-1 enzymes were measured. This led to the identification of L-766,112 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
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Published In
Bioorganic and Medicinal Chemistry Letters
DOI
ISSN
0960-894X
Publication Date
January 7, 1997
Volume
7
Issue
1
Start / End Page
47 / 52
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
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Thérien, M., Brideau, C., Chan, C. C., Cromlish, W. A., Gauthier, J. Y., Gordon, R., … Prasit, P. (1997). Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors. Bioorganic and Medicinal Chemistry Letters, 7(1), 47–52. https://doi.org/10.1016/S0960-894X(96)00580-X
Thérien, M., C. Brideau, C. C. Chan, W. A. Cromlish, J. Y. Gauthier, R. Gordon, G. Greig, et al. “Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors.” Bioorganic and Medicinal Chemistry Letters 7, no. 1 (January 7, 1997): 47–52. https://doi.org/10.1016/S0960-894X(96)00580-X.
Thérien M, Brideau C, Chan CC, Cromlish WA, Gauthier JY, Gordon R, et al. Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors. Bioorganic and Medicinal Chemistry Letters. 1997 Jan 7;7(1):47–52.
Thérien, M., et al. “Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors.” Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 1, Jan. 1997, pp. 47–52. Scopus, doi:10.1016/S0960-894X(96)00580-X.
Thérien M, Brideau C, Chan CC, Cromlish WA, Gauthier JY, Gordon R, Greig G, Kargman S, Lau CK, Leblanc Y, Li CS, O’Neill GP, Riendeau D, Roy P, Wang Z, Xu L, Prasit P. Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors. Bioorganic and Medicinal Chemistry Letters. 1997 Jan 7;7(1):47–52.
Published In
Bioorganic and Medicinal Chemistry Letters
DOI
ISSN
0960-894X
Publication Date
January 7, 1997
Volume
7
Issue
1
Start / End Page
47 / 52
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 1115 Pharmacology and Pharmaceutical Sciences
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry