Pyridazinones as selective cyclooxygenase-2 inhibitors.
Publication
, Journal Article
Li, CS; Brideau, C; Chan, CC; Savoie, C; Claveau, D; Charleson, S; Gordon, R; Greig, G; Gauthier, JY; Lau, CK; Riendeau, D; Thérien, M ...
Published in: Bioorganic & medicinal chemistry letters
February 2003
Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.
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Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
February 2003
Volume
13
Issue
4
Start / End Page
597 / 600
Related Subject Headings
- Structure-Activity Relationship
- Rats
- Pyridazines
- Prostaglandin-Endoperoxide Synthases
- Metabolic Clearance Rate
- Membrane Proteins
- Medicinal & Biomolecular Chemistry
- Isoenzymes
- Inhibitory Concentration 50
- Humans
Citation
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Li, C. S., Brideau, C., Chan, C. C., Savoie, C., Claveau, D., Charleson, S., … Prasit, P. (2003). Pyridazinones as selective cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters, 13(4), 597–600. https://doi.org/10.1016/s0960-894x(02)01045-4
Li, Chun Sing, Christine Brideau, Chi Chung Chan, Chantal Savoie, David Claveau, Stella Charleson, Robert Gordon, et al. “Pyridazinones as selective cyclooxygenase-2 inhibitors.” Bioorganic & Medicinal Chemistry Letters 13, no. 4 (February 2003): 597–600. https://doi.org/10.1016/s0960-894x(02)01045-4.
Li CS, Brideau C, Chan CC, Savoie C, Claveau D, Charleson S, et al. Pyridazinones as selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters. 2003 Feb;13(4):597–600.
Li, Chun Sing, et al. “Pyridazinones as selective cyclooxygenase-2 inhibitors.” Bioorganic & Medicinal Chemistry Letters, vol. 13, no. 4, Feb. 2003, pp. 597–600. Epmc, doi:10.1016/s0960-894x(02)01045-4.
Li CS, Brideau C, Chan CC, Savoie C, Claveau D, Charleson S, Gordon R, Greig G, Gauthier JY, Lau CK, Riendeau D, Thérien M, Wong E, Prasit P. Pyridazinones as selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters. 2003 Feb;13(4):597–600.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
February 2003
Volume
13
Issue
4
Start / End Page
597 / 600
Related Subject Headings
- Structure-Activity Relationship
- Rats
- Pyridazines
- Prostaglandin-Endoperoxide Synthases
- Metabolic Clearance Rate
- Membrane Proteins
- Medicinal & Biomolecular Chemistry
- Isoenzymes
- Inhibitory Concentration 50
- Humans