Synthesis of Rofecoxib, (MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2
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, Journal Article
Thérien, M; Yves Gauthier, J; Leblanc, Y; Lèger, S; Perrier, H; Prasit, P; Wang, Z
Published in: Synthesis
January 1, 2001
The synthesis of Vioxx® (Rofecoxib, MK 966, 4-(4′methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a newly FDA approved inhibitor of cyclooxygenase-2, is described.
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Published In
Synthesis
DOI
ISSN
0039-7881
Publication Date
January 1, 2001
Issue
12
Start / End Page
1778 / 1779
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 0305 Organic Chemistry
- 0301 Analytical Chemistry
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Thérien, M., Yves Gauthier, J., Leblanc, Y., Lèger, S., Perrier, H., Prasit, P., & Wang, Z. (2001). Synthesis of Rofecoxib, (MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2. Synthesis, (12), 1778–1779. https://doi.org/10.1055/s-2001-17519
Thérien, M., J. Yves Gauthier, Y. Leblanc, S. Lèger, H. Perrier, P. Prasit, and Z. Wang. “Synthesis of Rofecoxib, (MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2.” Synthesis, no. 12 (January 1, 2001): 1778–79. https://doi.org/10.1055/s-2001-17519.
Thérien M, Yves Gauthier J, Leblanc Y, Lèger S, Perrier H, Prasit P, et al. Synthesis of Rofecoxib, (MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2. Synthesis. 2001 Jan 1;(12):1778–9.
Thérien, M., et al. “Synthesis of Rofecoxib, (MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2.” Synthesis, no. 12, Jan. 2001, pp. 1778–79. Scopus, doi:10.1055/s-2001-17519.
Thérien M, Yves Gauthier J, Leblanc Y, Lèger S, Perrier H, Prasit P, Wang Z. Synthesis of Rofecoxib, (MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2. Synthesis. 2001 Jan 1;(12):1778–1779.
Published In
Synthesis
DOI
ISSN
0039-7881
Publication Date
January 1, 2001
Issue
12
Start / End Page
1778 / 1779
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 0305 Organic Chemistry
- 0301 Analytical Chemistry