Skip to main content

CT Accuracy of Extrinsic Tongue Muscle Invasion in Oral Cavity Cancer.

Publication ,  Journal Article
Junn, JC; Baugnon, KL; Lacayo, EA; Hudgins, PA; Patel, MR; Magliocca, KR; Corey, AS; El-Deiry, M; Wadsworth, JT; Beitler, JJ; Saba, NF; Liu, Y ...
Published in: AJNR Am J Neuroradiol
February 2017

BACKGROUND AND PURPOSE: Extrinsic tongue muscle invasion in oral cavity cancer upstages the primary tumor to a T4a. Despite this American Joint Committee on Cancer staging criterion, no studies have investigated the accuracy or prognostic importance of radiologic extrinsic tongue muscle invasion, the feasibility of standardizing extrinsic tongue muscle invasion reporting, or the degree of agreement across different disciplines: radiology, surgery, and pathology. The purpose of this study was to assess the agreement among radiology, surgery, and pathology for extrinsic tongue muscle invasion and to determine the imaging features most predictive of extrinsic tongue muscle invasion with surgical/pathologic confirmation. MATERIALS AND METHODS: Thirty-three patients with untreated primary oral cavity cancer were included. Two head and neck radiologists, 3 otolaryngologists, and 1 pathologist prospectively evaluated extrinsic tongue muscle invasion. RESULTS: Fourteen of 33 patients had radiologic extrinsic tongue muscle invasion; however, only 8 extrinsic tongue muscle invasions were confirmed intraoperatively. Pathologists were unable to determine extrinsic tongue muscle invasion in post-formalin-fixed samples. Radiologic extrinsic tongue muscle invasion had 100% sensitivity, 76% specificity, 57% positive predictive value, and 100% negative predictive value with concurrent surgical-pathologic evaluation of extrinsic tongue muscle invasion as the criterion standard. On further evaluation, the imaging characteristic most consistent with surgical-pathologic evaluation positive for extrinsic tongue muscle invasion was masslike enhancement. CONCLUSIONS: Evaluation of extrinsic tongue muscle invasion is a subjective finding for all 3 disciplines. For radiology, masslike enhancement of extrinsic tongue muscle invasion most consistently corresponded to concurrent surgery/pathology evaluation positive for extrinsic tongue muscle invasion. Intraoperative surgical and pathologic evaluation should be encouraged to verify radiologic extrinsic tongue muscle invasion to minimize unnecessary upstaging. Because this process is not routine, imaging can add value by identifying those cases most suspicious for extrinsic tongue muscle invasion, thereby prompting this more detailed evaluation by surgeons and pathologists.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

February 2017

Volume

38

Issue

2

Start / End Page

364 / 370

Location

United States

Related Subject Headings

  • Tongue
  • Tomography, X-Ray Computed
  • Retrospective Studies
  • Reproducibility of Results
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Staging
  • Muscle, Skeletal
  • Mouth Neoplasms
  • Mouth
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Junn, J. C., Baugnon, K. L., Lacayo, E. A., Hudgins, P. A., Patel, M. R., Magliocca, K. R., … Aiken, A. H. (2017). CT Accuracy of Extrinsic Tongue Muscle Invasion in Oral Cavity Cancer. AJNR Am J Neuroradiol, 38(2), 364–370. https://doi.org/10.3174/ajnr.A4993
Junn, J. C., K. L. Baugnon, E. A. Lacayo, P. A. Hudgins, M. R. Patel, K. R. Magliocca, A. S. Corey, et al. “CT Accuracy of Extrinsic Tongue Muscle Invasion in Oral Cavity Cancer.AJNR Am J Neuroradiol 38, no. 2 (February 2017): 364–70. https://doi.org/10.3174/ajnr.A4993.
Junn JC, Baugnon KL, Lacayo EA, Hudgins PA, Patel MR, Magliocca KR, et al. CT Accuracy of Extrinsic Tongue Muscle Invasion in Oral Cavity Cancer. AJNR Am J Neuroradiol. 2017 Feb;38(2):364–70.
Junn, J. C., et al. “CT Accuracy of Extrinsic Tongue Muscle Invasion in Oral Cavity Cancer.AJNR Am J Neuroradiol, vol. 38, no. 2, Feb. 2017, pp. 364–70. Pubmed, doi:10.3174/ajnr.A4993.
Junn JC, Baugnon KL, Lacayo EA, Hudgins PA, Patel MR, Magliocca KR, Corey AS, El-Deiry M, Wadsworth JT, Beitler JJ, Saba NF, Liu Y, Aiken AH. CT Accuracy of Extrinsic Tongue Muscle Invasion in Oral Cavity Cancer. AJNR Am J Neuroradiol. 2017 Feb;38(2):364–370.

Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

February 2017

Volume

38

Issue

2

Start / End Page

364 / 370

Location

United States

Related Subject Headings

  • Tongue
  • Tomography, X-Ray Computed
  • Retrospective Studies
  • Reproducibility of Results
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Staging
  • Muscle, Skeletal
  • Mouth Neoplasms
  • Mouth