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Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.

Publication ,  Journal Article
Peres, LC; Risch, H; Terry, KL; Webb, PM; Goodman, MT; Wu, AH; Alberg, AJ; Bandera, EV; Barnholtz-Sloan, J; Bondy, ML; Cote, ML; Funkhouser, E ...
Published in: Int J Epidemiol
April 1, 2018

BACKGROUND: Ovarian cancer incidence differs substantially by race/ethnicity, but the reasons for this are not well understood. Data were pooled from the African American Cancer Epidemiology Study (AACES) and 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC) to examine racial/ethnic differences in epidemiological characteristics with suspected involvement in epithelial ovarian cancer (EOC) aetiology. METHODS: We used multivariable logistic regression to estimate associations for 17 reproductive, hormonal and lifestyle characteristics and EOC risk by race/ethnicity among 10 924 women with invasive EOC (8918 Non-Hispanic Whites, 433 Hispanics, 911 Blacks, 662 Asian/Pacific Islanders) and 16 150 controls (13 619 Non-Hispanic Whites, 533 Hispanics, 1233 Blacks, 765 Asian/Pacific Islanders). Likelihood ratio tests were used to evaluate heterogeneity in the risk factor associations by race/ethnicity. RESULTS: We observed statistically significant racial/ethnic heterogeneity for hysterectomy and EOC risk (P = 0.008), where the largest odds ratio (OR) was observed in Black women [OR = 1.64, 95% confidence interval (CI) = 1.34-2.02] compared with other racial/ethnic groups. Although not statistically significant, the associations for parity, first-degree family history of ovarian or breast cancer, and endometriosis varied by race/ethnicity. Asian/Pacific Islanders had the greatest magnitude of association for parity (≥3 births: OR = 0.38, 95% CI = 0.28-0.54), and Black women had the largest ORs for family history (OR = 1.77, 95% CI = 1.42-2.21) and endometriosis (OR = 2.42, 95% CI = 1.65-3.55). CONCLUSIONS: Although racial/ethnic heterogeneity was observed for hysterectomy, our findings support the validity of EOC risk factors across all racial/ethnic groups, and further suggest that any racial/ethnic population with a higher prevalence of a modifiable risk factor should be targeted to disseminate information about prevention.

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Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

April 1, 2018

Volume

47

Issue

2

Start / End Page

460 / 472

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Risk Factors
  • Probability
  • Prevalence
  • Pregnancy
  • Parity
  • Ovarian Neoplasms
  • Multivariate Analysis
  • Middle Aged
 

Citation

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Peres, L. C., Risch, H., Terry, K. L., Webb, P. M., Goodman, M. T., Wu, A. H., … African American Cancer Epidemiology Study and the Ovarian Cancer Association Consortium, . (2018). Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. Int J Epidemiol, 47(2), 460–472. https://doi.org/10.1093/ije/dyx252
Peres, Lauren C., Harvey Risch, Kathryn L. Terry, Penelope M. Webb, Marc T. Goodman, Anna H. Wu, Anthony J. Alberg, et al. “Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.Int J Epidemiol 47, no. 2 (April 1, 2018): 460–72. https://doi.org/10.1093/ije/dyx252.
Peres LC, Risch H, Terry KL, Webb PM, Goodman MT, Wu AH, et al. Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. Int J Epidemiol. 2018 Apr 1;47(2):460–72.
Peres, Lauren C., et al. “Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies.Int J Epidemiol, vol. 47, no. 2, Apr. 2018, pp. 460–72. Pubmed, doi:10.1093/ije/dyx252.
Peres LC, Risch H, Terry KL, Webb PM, Goodman MT, Wu AH, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy ML, Cote ML, Funkhouser E, Moorman PG, Peters ES, Schwartz AG, Terry PD, Manichaikul A, Abbott SE, Camacho F, Jordan SJ, Nagle CM, Australian Ovarian Cancer Study Group, Rossing MA, Doherty JA, Modugno F, Moysich K, Ness R, Berchuck A, Cook L, Le N, Brooks-Wilson A, Sieh W, Whittemore A, McGuire V, Rothstein J, Anton-Culver H, Ziogas A, Pearce CL, Tseng C, Pike M, Schildkraut JM, African American Cancer Epidemiology Study and the Ovarian Cancer Association Consortium. Racial/ethnic differences in the epidemiology of ovarian cancer: a pooled analysis of 12 case-control studies. Int J Epidemiol. 2018 Apr 1;47(2):460–472.
Journal cover image

Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

April 1, 2018

Volume

47

Issue

2

Start / End Page

460 / 472

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Risk Factors
  • Probability
  • Prevalence
  • Pregnancy
  • Parity
  • Ovarian Neoplasms
  • Multivariate Analysis
  • Middle Aged