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Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.

Publication ,  Journal Article
Lilje, B; Rasmussen, RV; Dahl, A; Stegger, M; Skov, RL; Fowler, VG; Ng, KL; Kiil, K; Larsen, AR; Petersen, A; Johansen, HK; Schønheyder, HC ...
Published in: Microb Genom
November 2017

Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia.

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Published In

Microb Genom

DOI

EISSN

2057-5858

Publication Date

November 2017

Volume

3

Issue

11

Location

England

Related Subject Headings

  • Whole Genome Sequencing
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Polymorphism, Single Nucleotide
  • Humans
  • Endocarditis, Bacterial
  • Computational Biology
  • Bacteremia
  • 3107 Microbiology
  • 3105 Genetics
 

Citation

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Lilje, B., Rasmussen, R. V., Dahl, A., Stegger, M., Skov, R. L., Fowler, V. G., … Eske-Bruun, N. (2017). Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis. Microb Genom, 3(11). https://doi.org/10.1099/mgen.0.000138
Lilje, Berit, Rasmus Vedby Rasmussen, Anders Dahl, Marc Stegger, Robert Leo Skov, Vance G. Fowler, Kim Lee Ng, et al. “Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.Microb Genom 3, no. 11 (November 2017). https://doi.org/10.1099/mgen.0.000138.
Lilje B, Rasmussen RV, Dahl A, Stegger M, Skov RL, Fowler VG, et al. Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis. Microb Genom. 2017 Nov;3(11).
Lilje, Berit, et al. “Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.Microb Genom, vol. 3, no. 11, Nov. 2017. Pubmed, doi:10.1099/mgen.0.000138.
Lilje B, Rasmussen RV, Dahl A, Stegger M, Skov RL, Fowler VG, Ng KL, Kiil K, Larsen AR, Petersen A, Johansen HK, Schønheyder HC, Arpi M, Rosenvinge FS, Korup E, Høst U, Hassager C, Gill SUA, Hansen TF, Johannesen TB, Smit J, Søgaard P, Skytt Andersen P, Eske-Bruun N. Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis. Microb Genom. 2017 Nov;3(11).

Published In

Microb Genom

DOI

EISSN

2057-5858

Publication Date

November 2017

Volume

3

Issue

11

Location

England

Related Subject Headings

  • Whole Genome Sequencing
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Polymorphism, Single Nucleotide
  • Humans
  • Endocarditis, Bacterial
  • Computational Biology
  • Bacteremia
  • 3107 Microbiology
  • 3105 Genetics