
Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review.
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the United States. With the implementation of lung cancer screening, the number and proportion of patients diagnosed with early-stage disease are anticipated to increase. Surgery is currently the standard of care for patients with operable stage I NSCLC. However, promising outcomes with stereotactic body radiation therapy (SBRT) in patients with inoperable disease has led to interest in directly comparing SBRT and surgery in operable patients. Unfortunately, early randomized trials comparing surgery and SBRT closed early because of poor accrual. In this article, the nuances of surgery and SBRT for early-stage NSCLC are reviewed. Furthermore, retrospective and prospective analyses of SBRT in early-stage NSCLC are discussed, and active randomized trials comparing these 2 approaches are described. Cancer 2018;124:667-78. © 2017 American Cancer Society.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Randomized Controlled Trials as Topic
- Radiosurgery
- Pneumonectomy
- Oncology & Carcinogenesis
- Neoplasm Staging
- Neoplasm Recurrence, Local
- Lung Neoplasms
- Humans
- Disease-Free Survival
- Carcinoma, Non-Small-Cell Lung
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Randomized Controlled Trials as Topic
- Radiosurgery
- Pneumonectomy
- Oncology & Carcinogenesis
- Neoplasm Staging
- Neoplasm Recurrence, Local
- Lung Neoplasms
- Humans
- Disease-Free Survival
- Carcinoma, Non-Small-Cell Lung