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Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study

Publication ,  Conference
Edwards, JM; Watson, N; Focht, C; Wynn, C; Todd, CA; Walter, EB; Phillips Heine, R; Swamy, GK
Published in: Infectious Diseases in Obstetrics and Gynecology
January 1, 2019

Background. Maternal GBS colonization is associated with early-onset neonatal sepsis and extensive efforts are directed to preventing this complication. Less is known about maternal risks of GBS colonization. We seek to provide a modern estimate of the incidence and impact of maternal GBS colonization and invasive GBS disease. Methods. A single center historical cohort study of all births between 2003 and 2015 was performed. Data was collected via electronic health record abstraction using an institutional specific tool. Descriptive statistics were performed regarding GBS status. Inferential statistics were performed comparing risk of adverse pregnancy outcomes in cohorts with and without GBS colonization as well as cohorts with GBS colonization and invasive GBS disease. Results. A total of 60,029 deliveries were included for analysis. Overall, 21.6% of the population was GBS colonized and 0.1% had invasive GBS disease. GBS colonization was associated with younger maternal age, Black race, non-Hispanic ethnicity, chronic hypertension, preexisting diabetes, and tobacco use (p<0.01). In the adjusted analyses, there was an increased risk of gestational diabetes (aRR 1.21, 95% CI 1.11-1.32) in colonized pregnancies and a decreased incidence of short cervix (aRR 0.64, 95% CI 0.52-0.79), chorioamnionitis (aRR 0.76, 95% CI 0.66-0.87), wound infection (aRR 0.75, 95% CI 0.64-0.88), and operative delivery (aRR 0.85, 95% CI 0.83-0.88). Conclusions. This modern-day large cohort of all births over a 12-year period demonstrates a GBS colonization rate of 21.6%. This data reflects a need to assess maternal and perinatal outcomes in addition to neonatal GBS sepsis rates to inform decisions regarding the utility of maternal vaccination.

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Published In

Infectious Diseases in Obstetrics and Gynecology

DOI

EISSN

1098-0997

ISSN

1064-7449

Publication Date

January 1, 2019

Volume

2019

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 3207 Medical microbiology
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

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Chicago
ICMJE
MLA
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Edwards, J. M., Watson, N., Focht, C., Wynn, C., Todd, C. A., Walter, E. B., … Swamy, G. K. (2019). Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study. In Infectious Diseases in Obstetrics and Gynecology (Vol. 2019). https://doi.org/10.1155/2019/5430493
Edwards, J. M., N. Watson, C. Focht, C. Wynn, C. A. Todd, E. B. Walter, R. Phillips Heine, and G. K. Swamy. “Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.” In Infectious Diseases in Obstetrics and Gynecology, Vol. 2019, 2019. https://doi.org/10.1155/2019/5430493.
Edwards JM, Watson N, Focht C, Wynn C, Todd CA, Walter EB, et al. Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study. In: Infectious Diseases in Obstetrics and Gynecology. 2019.
Edwards, J. M., et al. “Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.” Infectious Diseases in Obstetrics and Gynecology, vol. 2019, 2019. Scopus, doi:10.1155/2019/5430493.
Edwards JM, Watson N, Focht C, Wynn C, Todd CA, Walter EB, Phillips Heine R, Swamy GK. Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study. Infectious Diseases in Obstetrics and Gynecology. 2019.
Journal cover image

Published In

Infectious Diseases in Obstetrics and Gynecology

DOI

EISSN

1098-0997

ISSN

1064-7449

Publication Date

January 1, 2019

Volume

2019

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 3207 Medical microbiology
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology