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Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs.

Publication ,  Journal Article
Caspi, A; Reichenberg, A; Weiser, M; Rabinowitz, J; Shmushkevich, M; Lubin, G; Nahon, D; Vishne, T; Davidson, M
Published in: Schizophrenia research
August 2007

Approximately one third of schizophrenia patients show partial or no response to pharmacotherapy. Despite intensive investigations, the phenomenological and biological characteristics of such patients are far from elucidated. This study examined the premorbid behavioral and intellectual functioning of schizophrenia patients who showed poor response to antipsychotic treatment.One hundred twenty-nine schizophrenia patients who showed poor response to treatment were ascertained from a national register and matched by gender, age and education to 129 patients who showed adequate response. The groups were compared on premorbid measures of behavioral and intellectual functions.As a group, treatment-resistant male patients had significantly lower (worse) social functioning [p=0.002], and individual autonomy [p<0.0001] scores before the onset of the illness compared to treatment non-resistant patients. Male and female treatment-resistant patients did not differ from non-resistant patients in premorbid intellectual functioning [p>0.1].Low premorbid social functioning and individual autonomy, but not intellectual functioning, could serve as predictors of poor treatment response in schizophrenia.

Duke Scholars

Published In

Schizophrenia research

DOI

EISSN

1573-2509

ISSN

0920-9964

Publication Date

August 2007

Volume

94

Issue

1-3

Start / End Page

45 / 49

Related Subject Headings

  • Social Behavior
  • Schizophrenia
  • Registries
  • Psychiatry
  • Neuropsychological Tests
  • Mental Disorders
  • Male
  • Humans
  • Female
  • Drug Resistance
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Caspi, A., Reichenberg, A., Weiser, M., Rabinowitz, J., Shmushkevich, M., Lubin, G., … Davidson, M. (2007). Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs. Schizophrenia Research, 94(1–3), 45–49. https://doi.org/10.1016/j.schres.2007.04.007
Caspi, Asaf, Abraham Reichenberg, Mark Weiser, Jonathan Rabinowitz, Motti Shmushkevich, Gad Lubin, Daniella Nahon, Tali Vishne, and Michael Davidson. “Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs.Schizophrenia Research 94, no. 1–3 (August 2007): 45–49. https://doi.org/10.1016/j.schres.2007.04.007.
Caspi A, Reichenberg A, Weiser M, Rabinowitz J, Shmushkevich M, Lubin G, et al. Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs. Schizophrenia research. 2007 Aug;94(1–3):45–9.
Caspi, Asaf, et al. “Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs.Schizophrenia Research, vol. 94, no. 1–3, Aug. 2007, pp. 45–49. Epmc, doi:10.1016/j.schres.2007.04.007.
Caspi A, Reichenberg A, Weiser M, Rabinowitz J, Shmushkevich M, Lubin G, Nahon D, Vishne T, Davidson M. Premorbid behavioral and intellectual functioning in schizophrenia patients with poor response to treatment with antipsychotic drugs. Schizophrenia research. 2007 Aug;94(1–3):45–49.
Journal cover image

Published In

Schizophrenia research

DOI

EISSN

1573-2509

ISSN

0920-9964

Publication Date

August 2007

Volume

94

Issue

1-3

Start / End Page

45 / 49

Related Subject Headings

  • Social Behavior
  • Schizophrenia
  • Registries
  • Psychiatry
  • Neuropsychological Tests
  • Mental Disorders
  • Male
  • Humans
  • Female
  • Drug Resistance