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Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.

Publication ,  Journal Article
McCarthy, KR; Watanabe, A; Kuraoka, M; Do, KT; McGee, CE; Sempowski, GD; Kepler, TB; Schmidt, AG; Kelsoe, G; Harrison, SC
Published in: Immunity
January 16, 2018

Human B cell antigen-receptor (BCR) repertoires reflect repeated exposures to evolving influenza viruses; new exposures update the previously generated B cell memory (Bmem) population. Despite structural similarity of hemagglutinins (HAs) from the two groups of influenza A viruses, cross-reacting antibodies (Abs) are uncommon. We analyzed Bmem compartments in three unrelated, adult donors and found frequent cross-group BCRs, both HA-head directed and non-head directed. Members of a clonal lineage from one donor had a BCR structure similar to that of a previously described Ab, encoded by different gene segments. Comparison showed that both Abs contacted the HA receptor-binding site through long heavy-chain third complementarity determining regions. Affinities of the clonal-lineage BCRs for historical influenza-virus HAs from both group 1 and group 2 viruses suggested that serial responses to seasonal influenza exposures had elicited the lineage and driven affinity maturation. We propose that appropriate immunization regimens might elicit a comparably broad response.

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Published In

Immunity

DOI

EISSN

1097-4180

Publication Date

January 16, 2018

Volume

48

Issue

1

Start / End Page

174 / 184.e9

Location

United States

Related Subject Headings

  • Male
  • Interferometry
  • Influenza A virus
  • Immunology
  • Humans
  • Hemagglutinins, Viral
  • Flow Cytometry
  • Female
  • Cross Reactions
  • Cell Culture Techniques
 

Citation

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McCarthy, K. R., Watanabe, A., Kuraoka, M., Do, K. T., McGee, C. E., Sempowski, G. D., … Harrison, S. C. (2018). Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity, 48(1), 174-184.e9. https://doi.org/10.1016/j.immuni.2017.12.009
McCarthy, Kevin R., Akiko Watanabe, Masayuki Kuraoka, Khoi T. Do, Charles E. McGee, Gregory D. Sempowski, Thomas B. Kepler, Aaron G. Schmidt, Garnett Kelsoe, and Stephen C. Harrison. “Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.Immunity 48, no. 1 (January 16, 2018): 174-184.e9. https://doi.org/10.1016/j.immuni.2017.12.009.
McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, et al. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity. 2018 Jan 16;48(1):174-184.e9.
McCarthy, Kevin R., et al. “Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.Immunity, vol. 48, no. 1, Jan. 2018, pp. 174-184.e9. Pubmed, doi:10.1016/j.immuni.2017.12.009.
McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Kepler TB, Schmidt AG, Kelsoe G, Harrison SC. Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity. 2018 Jan 16;48(1):174-184.e9.
Journal cover image

Published In

Immunity

DOI

EISSN

1097-4180

Publication Date

January 16, 2018

Volume

48

Issue

1

Start / End Page

174 / 184.e9

Location

United States

Related Subject Headings

  • Male
  • Interferometry
  • Influenza A virus
  • Immunology
  • Humans
  • Hemagglutinins, Viral
  • Flow Cytometry
  • Female
  • Cross Reactions
  • Cell Culture Techniques