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Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance).

Publication ,  Journal Article
Van Blarigan, EL; Fuchs, CS; Niedzwiecki, D; Ye, X; Zhang, S; Song, M; Saltz, LB; Mayer, RJ; Mowat, RB; Whittom, R; Hantel, A; Benson, A ...
Published in: Cancer Epidemiol Biomarkers Prev
April 2018

Background: Marine ω-3 polyunsaturated fatty acids (PUFAs), primarily found in dark fish, may prevent colorectal cancer progression, in part through inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2). However, data in humans are limited.Methods: We examined marine ω-3 PUFAs and fish intake and survival among 1,011 colon cancer patients enrolled in Cancer and Leukemia Group B 89803 between 1999 and 2001 and followed through 2009. Diet was assessed during and 6 months after chemotherapy. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for disease-free (DFS), recurrence-free (RFS), and overall survival (OS).Results: We observed 343 recurrences and 305 deaths (median follow-up: 7 years). Patients in the highest vs. lowest quartile of marine ω-3 PUFA intake had an HR for DFS of 0.72 (95% CI, 0.54-0.97; Ptrend = 0.03). Individuals who consumed dark fish ≥1/week versus never had longer DFS (HR 0.65; 95% CI, 0.48-0.87; P-value = 0.007), RFS (HR 0.61; 95% CI, 0.46-0.86; Ptrend = 0.007), and OS (HR 0.68; 95% CI, 0.48-0.96; Ptrend = 0.04). In a subset of 510 patients, the association between marine ω-3 PUFA intake and DFS appeared stronger in patients with high PTGS2 expression (HR 0.32; 95% CI, 0.11-0.95; Ptrend = 0.01) compared with patients with absent/low PTGS2 expression (HR 0.78; 95% CI, 0.48-1.27; Ptrend = 0.35; Pinteraction = 0.19).Conclusions: Patients with high intake of marine ω-3 PUFAs and dark fish after colon cancer diagnosis may have longer DFS.Impact: Randomized controlled trials examining dark fish and/or marine ω-3 PUFA supplements and colon cancer recurrence/survival are needed. Cancer Epidemiol Biomarkers Prev; 27(4); 438-45. ©2018 AACR.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 2018

Volume

27

Issue

4

Start / End Page

438 / 445

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Seafood
  • Risk Factors
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Fishes
  • Female
  • Feeding Behavior
 

Citation

APA
Chicago
ICMJE
MLA
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Van Blarigan, E. L., Fuchs, C. S., Niedzwiecki, D., Ye, X., Zhang, S., Song, M., … Meyerhardt, J. A. (2018). Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev, 27(4), 438–445. https://doi.org/10.1158/1055-9965.EPI-17-0689
Van Blarigan, Erin L., Charles S. Fuchs, Donna Niedzwiecki, Xing Ye, Sui Zhang, Mingyang Song, Leonard B. Saltz, et al. “Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance).Cancer Epidemiol Biomarkers Prev 27, no. 4 (April 2018): 438–45. https://doi.org/10.1158/1055-9965.EPI-17-0689.
Van Blarigan EL, Fuchs CS, Niedzwiecki D, Ye X, Zhang S, Song M, et al. Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev. 2018 Apr;27(4):438–45.
Van Blarigan, Erin L., et al. “Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance).Cancer Epidemiol Biomarkers Prev, vol. 27, no. 4, Apr. 2018, pp. 438–45. Pubmed, doi:10.1158/1055-9965.EPI-17-0689.
Van Blarigan EL, Fuchs CS, Niedzwiecki D, Ye X, Zhang S, Song M, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Ogino S, Giovannucci EL, Meyerhardt JA. Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev. 2018 Apr;27(4):438–445.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 2018

Volume

27

Issue

4

Start / End Page

438 / 445

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Seafood
  • Risk Factors
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Fishes
  • Female
  • Feeding Behavior