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Complement system in lung transplantation.

Publication ,  Journal Article
Ali, HA; Pavlisko, EN; Snyder, LD; Frank, M; Palmer, SM
Published in: Clin Transplant
April 2018

The complement system is a cascade of multiple proteins that have been known to mediate inflammatory response. This tightly regulated system has been recognized to play a role in adaptive immunity via humoral and cell-mediated processes. There is evidence from animal and human studies that the complement system is involved in various outcomes of solid organ transplantation. Most of the studies have been done in the field of kidney transplantation. In this paper, we review the studies looking at lung transplantation. The complement cascade appears to have a prominent role in mediating lung allograft damage in the setting of ischemia-reperfusion injury, humoral rejection, as well as chronic allograft dysfunction. In this review, we look at the available data regarding the role of complement in these outcomes and propose some ideas about future direction of research in this field.

Duke Scholars

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

April 2018

Volume

32

Issue

4

Start / End Page

e13208

Location

Denmark

Related Subject Headings

  • Surgery
  • Lung Transplantation
  • Humans
  • Graft Rejection
  • Complement System Proteins
  • Complement Activation
  • Animals
  • Adaptive Immunity
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ali, H. A., Pavlisko, E. N., Snyder, L. D., Frank, M., & Palmer, S. M. (2018). Complement system in lung transplantation. Clin Transplant, 32(4), e13208. https://doi.org/10.1111/ctr.13208
Ali, Hakim Azfar, Elizabeth N. Pavlisko, Laurie D. Snyder, Michael Frank, and Scott M. Palmer. “Complement system in lung transplantation.Clin Transplant 32, no. 4 (April 2018): e13208. https://doi.org/10.1111/ctr.13208.
Ali HA, Pavlisko EN, Snyder LD, Frank M, Palmer SM. Complement system in lung transplantation. Clin Transplant. 2018 Apr;32(4):e13208.
Ali, Hakim Azfar, et al. “Complement system in lung transplantation.Clin Transplant, vol. 32, no. 4, Apr. 2018, p. e13208. Pubmed, doi:10.1111/ctr.13208.
Ali HA, Pavlisko EN, Snyder LD, Frank M, Palmer SM. Complement system in lung transplantation. Clin Transplant. 2018 Apr;32(4):e13208.
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

April 2018

Volume

32

Issue

4

Start / End Page

e13208

Location

Denmark

Related Subject Headings

  • Surgery
  • Lung Transplantation
  • Humans
  • Graft Rejection
  • Complement System Proteins
  • Complement Activation
  • Animals
  • Adaptive Immunity
  • 3202 Clinical sciences
  • 1103 Clinical Sciences