Skip to main content
construction release_alert
Images are temporarily unavailable. The scholars team is working with OIT and DHTS to fix the issue.
cancel
Journal cover image

TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.

Publication ,  Journal Article
Ortíz-Rentería, M; Juárez-Contreras, R; González-Ramírez, R; Islas, LD; Sierra-Ramírez, F; Llorente, I; Simon, SA; Hiriart, M; Rosenbaum, T ...
Published in: Proc Natl Acad Sci U S A
February 13, 2018

The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed in nociceptors where, when activated by chemical or thermal stimuli, it functions as an important transducer of painful and itch-related stimuli. Although the interaction of TRPV1 with proteins that regulate its function has been previously explored, their modulation by chaperones has not been elucidated, as is the case for other mammalian TRP channels. Here we show that TRPV1 physically interacts with the Sigma 1 Receptor (Sig-1R), a chaperone that binds progesterone, an antagonist of Sig-1R and an important neurosteroid associated to the modulation of pain. Antagonism of Sig-1R by progesterone results in the down-regulation of TRPV1 expression in the plasma membrane of sensory neurons and, consequently, a decrease in capsaicin-induced nociceptive responses. This is observed both in males treated with a synthetic antagonist of Sig-1R and in pregnant females where progesterone levels are elevated. This constitutes a previously undescribed mechanism by which TRPV1-dependent nociception and pain can be regulated.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

February 13, 2018

Volume

115

Issue

7

Start / End Page

E1657 / E1666

Location

United States

Related Subject Headings

  • TRPV Cation Channels
  • Sigma-1 Receptor
  • Sensory Receptor Cells
  • Receptors, sigma
  • Protein Binding
  • Progesterone
  • Pain
  • Mice, Inbred C57BL
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ortíz-Rentería, M., Juárez-Contreras, R., González-Ramírez, R., Islas, L. D., Sierra-Ramírez, F., Llorente, I., … Morales-Lázaro, S. L. (2018). TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Proc Natl Acad Sci U S A, 115(7), E1657–E1666. https://doi.org/10.1073/pnas.1715972115
Ortíz-Rentería, Miguel, Rebeca Juárez-Contreras, Ricardo González-Ramírez, León D. Islas, Félix Sierra-Ramírez, Itzel Llorente, Sidney A. Simon, Marcia Hiriart, Tamara Rosenbaum, and Sara L. Morales-Lázaro. “TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.Proc Natl Acad Sci U S A 115, no. 7 (February 13, 2018): E1657–66. https://doi.org/10.1073/pnas.1715972115.
Ortíz-Rentería M, Juárez-Contreras R, González-Ramírez R, Islas LD, Sierra-Ramírez F, Llorente I, et al. TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1657–66.
Ortíz-Rentería, Miguel, et al. “TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.Proc Natl Acad Sci U S A, vol. 115, no. 7, Feb. 2018, pp. E1657–66. Pubmed, doi:10.1073/pnas.1715972115.
Ortíz-Rentería M, Juárez-Contreras R, González-Ramírez R, Islas LD, Sierra-Ramírez F, Llorente I, Simon SA, Hiriart M, Rosenbaum T, Morales-Lázaro SL. TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1657–E1666.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

February 13, 2018

Volume

115

Issue

7

Start / End Page

E1657 / E1666

Location

United States

Related Subject Headings

  • TRPV Cation Channels
  • Sigma-1 Receptor
  • Sensory Receptor Cells
  • Receptors, sigma
  • Protein Binding
  • Progesterone
  • Pain
  • Mice, Inbred C57BL
  • Mice
  • Male