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Epigenetic regulation of male fate commitment from an initially bipotential system.

Publication ,  Journal Article
Garcia-Moreno, SA; Plebanek, MP; Capel, B
Published in: Mol Cell Endocrinol
June 15, 2018

A fundamental goal in biology is to understand how distinct cell types containing the same genetic information arise from a single stem cell throughout development. Sex determination is a key developmental process that requires a unidirectional commitment of an initially bipotential gonad towards either the male or female fate. This makes sex determination a unique model to study cell fate commitment and differentiation in vivo. We have focused this review on the accumulating evidence that epigenetic mechanisms contribute to the bipotential state of the fetal gonad and to the regulation of chromatin accessibility during and immediately downstream of the primary sex-determining switch that establishes the male fate.

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Published In

Mol Cell Endocrinol

DOI

EISSN

1872-8057

Publication Date

June 15, 2018

Volume

468

Start / End Page

19 / 30

Location

Ireland

Related Subject Headings

  • SOX Transcription Factors
  • Male
  • Histones
  • Genes, sry
  • Epigenesis, Genetic
  • Endocrinology & Metabolism
  • DNA Methylation
  • Chromatin
  • Animals
  • 3202 Clinical sciences
 

Citation

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ICMJE
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Garcia-Moreno, S. A., Plebanek, M. P., & Capel, B. (2018). Epigenetic regulation of male fate commitment from an initially bipotential system. Mol Cell Endocrinol, 468, 19–30. https://doi.org/10.1016/j.mce.2018.01.009
Garcia-Moreno, S Alexandra, Michael P. Plebanek, and Blanche Capel. “Epigenetic regulation of male fate commitment from an initially bipotential system.Mol Cell Endocrinol 468 (June 15, 2018): 19–30. https://doi.org/10.1016/j.mce.2018.01.009.
Garcia-Moreno SA, Plebanek MP, Capel B. Epigenetic regulation of male fate commitment from an initially bipotential system. Mol Cell Endocrinol. 2018 Jun 15;468:19–30.
Garcia-Moreno, S. Alexandra, et al. “Epigenetic regulation of male fate commitment from an initially bipotential system.Mol Cell Endocrinol, vol. 468, June 2018, pp. 19–30. Pubmed, doi:10.1016/j.mce.2018.01.009.
Garcia-Moreno SA, Plebanek MP, Capel B. Epigenetic regulation of male fate commitment from an initially bipotential system. Mol Cell Endocrinol. 2018 Jun 15;468:19–30.
Journal cover image

Published In

Mol Cell Endocrinol

DOI

EISSN

1872-8057

Publication Date

June 15, 2018

Volume

468

Start / End Page

19 / 30

Location

Ireland

Related Subject Headings

  • SOX Transcription Factors
  • Male
  • Histones
  • Genes, sry
  • Epigenesis, Genetic
  • Endocrinology & Metabolism
  • DNA Methylation
  • Chromatin
  • Animals
  • 3202 Clinical sciences