Skip to main content

Ryk controls remapping of motor cortex during functional recovery after spinal cord injury.

Publication ,  Journal Article
Hollis, ER; Ishiko, N; Yu, T; Lu, C-C; Haimovich, A; Tolentino, K; Richman, A; Tury, A; Wang, S-H; Pessian, M; Jo, E; Kolodkin, A; Zou, Y
Published in: Nat Neurosci
May 2016

Limited functional recovery can be achieved through rehabilitation after incomplete spinal cord injury. Eliminating the function of a repulsive Wnt receptor, Ryk, in mice and rats by either conditional knockout in the motor cortex or monoclonal antibody infusion resulted in increased corticospinal axon collateral branches with presynaptic puncta in the spinal cord and enhanced recovery of forelimb reaching and grasping function following a cervical dorsal column lesion. Using optical stimulation, we observed that motor cortical output maps underwent massive changes after injury and that hindlimb cortical areas were recruited to control the forelimb over time. Furthermore, a greater cortical area was dedicated to controlling the forelimb in Ryk conditional knockout mice than in controls (wild-type or heterozygotes). In the absence of weekly task-specific training, recruitment of ectopic cortical areas was greatly reduced and there was no significant functional recovery even in Ryk conditional knockout mice. Our study provides evidence that maximal circuit reorganization and functional recovery can be achieved by combining molecular manipulation and targeted rehabilitation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

May 2016

Volume

19

Issue

5

Start / End Page

697 / 705

Location

United States

Related Subject Headings

  • Spinal Cord Injuries
  • Recovery of Function
  • Receptor Protein-Tyrosine Kinases
  • Rats
  • Pyramidal Tracts
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Motor Cortex
  • Mice, Transgenic
  • Mice, Knockout
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hollis, E. R., Ishiko, N., Yu, T., Lu, C.-C., Haimovich, A., Tolentino, K., … Zou, Y. (2016). Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nat Neurosci, 19(5), 697–705. https://doi.org/10.1038/nn.4282
Hollis, Edmund R., Nao Ishiko, Ting Yu, Chin-Chun Lu, Ariela Haimovich, Kristine Tolentino, Alisha Richman, et al. “Ryk controls remapping of motor cortex during functional recovery after spinal cord injury.Nat Neurosci 19, no. 5 (May 2016): 697–705. https://doi.org/10.1038/nn.4282.
Hollis ER, Ishiko N, Yu T, Lu C-C, Haimovich A, Tolentino K, et al. Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nat Neurosci. 2016 May;19(5):697–705.
Hollis, Edmund R., et al. “Ryk controls remapping of motor cortex during functional recovery after spinal cord injury.Nat Neurosci, vol. 19, no. 5, May 2016, pp. 697–705. Pubmed, doi:10.1038/nn.4282.
Hollis ER, Ishiko N, Yu T, Lu C-C, Haimovich A, Tolentino K, Richman A, Tury A, Wang S-H, Pessian M, Jo E, Kolodkin A, Zou Y. Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nat Neurosci. 2016 May;19(5):697–705.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

May 2016

Volume

19

Issue

5

Start / End Page

697 / 705

Location

United States

Related Subject Headings

  • Spinal Cord Injuries
  • Recovery of Function
  • Receptor Protein-Tyrosine Kinases
  • Rats
  • Pyramidal Tracts
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Motor Cortex
  • Mice, Transgenic
  • Mice, Knockout