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Disparities in viral load and CD4 count trends among HIV-infected adults in South Carolina.

Publication ,  Journal Article
Chakraborty, H; Iyer, M; Duffus, WA; Samantapudi, AV; Albrecht, H; Weissman, S
Published in: AIDS Patient Care STDS
January 2015

On a population level, trends in viral load (VL) and CD4 cell counts can provide a marker of infectivity and an indirect measure of retention in care. Thus, observing the trend of CD4/VL over time can provide useful information on disparities in populations across the HIV care continuum when stratified by demography. South Carolina (SC) maintains electronic records of all CD4 cell counts and HIV VL measurements reported to the state health department. We examined temporal trends in individual HIV VLs reported in SC between January 1, 2005 and December 31, 2012 by using mixed effects models adjusting for gender, race/ethnicity, age, baseline CD4 count, HIV risk category, and residence. Overall VL levels gradually decreased over the observation period. There were significant differences in the VL decline by gender, age groups, rural/urban residence, and HIV risk exposure group. There were significant differences in CD4 increases by race/ethnicity, age groups, and HIV risk exposure group. However, the population VL declines were slower among individuals aged 13-19 years compared to older age groups (p<0.0001), among men compared to women (p=0.002), and among people living with HIV/AIDS (PLWHA) with CD4 count ≤200 cell/mm(3) compared to those with higher CD4 counts (p<0.0001). Significant disparities were observed in VL decline by gender, age, and CD4 counts among PLWHA in SC. Population based data such as these can help streamline and better target local resources to facilitate retention in care and adherence to medications among PLWHA.

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Published In

AIDS Patient Care STDS

DOI

EISSN

1557-7449

Publication Date

January 2015

Volume

29

Issue

1

Start / End Page

26 / 32

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Viral Load
  • South Carolina
  • Socioeconomic Factors
  • Sex Distribution
  • Residence Characteristics
  • RNA, Viral
  • Population Surveillance
  • Outcome and Process Assessment, Health Care
 

Citation

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Chicago
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Chakraborty, H., Iyer, M., Duffus, W. A., Samantapudi, A. V., Albrecht, H., & Weissman, S. (2015). Disparities in viral load and CD4 count trends among HIV-infected adults in South Carolina. AIDS Patient Care STDS, 29(1), 26–32. https://doi.org/10.1089/apc.2014.0158
Chakraborty, Hrishikesh, Medha Iyer, Wayne A. Duffus, Ashok Varma Samantapudi, Helmut Albrecht, and Sharon Weissman. “Disparities in viral load and CD4 count trends among HIV-infected adults in South Carolina.AIDS Patient Care STDS 29, no. 1 (January 2015): 26–32. https://doi.org/10.1089/apc.2014.0158.
Chakraborty H, Iyer M, Duffus WA, Samantapudi AV, Albrecht H, Weissman S. Disparities in viral load and CD4 count trends among HIV-infected adults in South Carolina. AIDS Patient Care STDS. 2015 Jan;29(1):26–32.
Chakraborty, Hrishikesh, et al. “Disparities in viral load and CD4 count trends among HIV-infected adults in South Carolina.AIDS Patient Care STDS, vol. 29, no. 1, Jan. 2015, pp. 26–32. Pubmed, doi:10.1089/apc.2014.0158.
Chakraborty H, Iyer M, Duffus WA, Samantapudi AV, Albrecht H, Weissman S. Disparities in viral load and CD4 count trends among HIV-infected adults in South Carolina. AIDS Patient Care STDS. 2015 Jan;29(1):26–32.
Journal cover image

Published In

AIDS Patient Care STDS

DOI

EISSN

1557-7449

Publication Date

January 2015

Volume

29

Issue

1

Start / End Page

26 / 32

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Viral Load
  • South Carolina
  • Socioeconomic Factors
  • Sex Distribution
  • Residence Characteristics
  • RNA, Viral
  • Population Surveillance
  • Outcome and Process Assessment, Health Care