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Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer.

Publication ,  Journal Article
Jiang, L; Zhang, X; Xiang, C; Geradts, J; Wei, Q; Liang, Y; Huang, H; Xu, J-F
Published in: Histol Histopathol
August 2018

CELSR2 is postulated to be a receptor involved in contact-mediated communication; however, its expression and function in cancer remain unknown. ING4 is a tumor suppresor encoded by the ING4 gene which inhibits cell growth. The expression of CELSR2 and ING4 in breast tumors and in benign epithelial cells have been analyzed and correlated with HER2, ER, and PR status. Immunohistochemistry was used to analyze the expression of CELSR2 and ING4 protein in breast tumors and benign epithelial cells. The differential cellular localization of both markers was analyzed and results were also correlated with HER2, ER, and PR status. CELSR2 and ING4 cytoplasmic expression was significantly stronger in tumors than in benign epithelial cells, while the nuclear expression of both markers was significantly stronger in benign epithelial cells than in tumors. When comparing the two markers in the same type of tissues, the nuclear expression of CELSR2 was significantly stronger than cytoplasmic in benign epithelial cells, while there was no significant difference in the cellular localization of CELSR2 in tumors. For ING4, the cytoplasmic expression was significantly stronger than nuclear expression in tumors, while in benign epithelial cells, ING4 was expressed at similar levels in both compartments. There was no correlation between CELSR2 expression and HER2, ER, and PR status in tumors. However, the cytoplasmic expression of ING4 was associated with HER2 positivity in tumors. Both CELSR2 and ING4 display increased cytoplasmic staining in breast cancer cells compared to benign epithelium, suggesting a possible role of both genes in the pathogenesis of human mammary neoplasia.

Duke Scholars

Published In

Histol Histopathol

DOI

EISSN

1699-5848

Publication Date

August 2018

Volume

33

Issue

8

Start / End Page

835 / 842

Location

Spain

Related Subject Headings

  • Tumor Suppressor Proteins
  • Triple Negative Breast Neoplasms
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Oncology & Carcinogenesis
  • Immunohistochemistry
  • Humans
  • Homeodomain Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jiang, L., Zhang, X., Xiang, C., Geradts, J., Wei, Q., Liang, Y., … Xu, J.-F. (2018). Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. Histol Histopathol, 33(8), 835–842. https://doi.org/10.14670/HH-11-979
Jiang, Liejun, Xiliu Zhang, Chenglin Xiang, Joseph Geradts, Qiang Wei, Yuanzi Liang, Huayi Huang, and Jun-Fa Xu. “Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer.Histol Histopathol 33, no. 8 (August 2018): 835–42. https://doi.org/10.14670/HH-11-979.
Jiang L, Zhang X, Xiang C, Geradts J, Wei Q, Liang Y, et al. Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. Histol Histopathol. 2018 Aug;33(8):835–42.
Jiang, Liejun, et al. “Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer.Histol Histopathol, vol. 33, no. 8, Aug. 2018, pp. 835–42. Pubmed, doi:10.14670/HH-11-979.
Jiang L, Zhang X, Xiang C, Geradts J, Wei Q, Liang Y, Huang H, Xu J-F. Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. Histol Histopathol. 2018 Aug;33(8):835–842.

Published In

Histol Histopathol

DOI

EISSN

1699-5848

Publication Date

August 2018

Volume

33

Issue

8

Start / End Page

835 / 842

Location

Spain

Related Subject Headings

  • Tumor Suppressor Proteins
  • Triple Negative Breast Neoplasms
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Oncology & Carcinogenesis
  • Immunohistochemistry
  • Humans
  • Homeodomain Proteins