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In situ forming injectable hydrogels for drug delivery and wound repair.

Publication ,  Journal Article
Dimatteo, R; Darling, NJ; Segura, T
Published in: Advanced drug delivery reviews
March 2018

Hydrogels have been utilized in regenerative applications for many decades because of their biocompatibility and similarity in structure to the native extracellular matrix. Initially, these materials were formed outside of the patient and implanted using invasive surgical techniques. However, advances in synthetic chemistry and materials science have now provided researchers with a library of techniques whereby hydrogel formation can occur in situ upon delivery through standard needles. This provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body. In this review, we highlight these injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair.

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Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

March 2018

Volume

127

Start / End Page

167 / 184

Related Subject Headings

  • Wound Healing
  • Tissue Engineering
  • Pharmacology & Pharmacy
  • Particle Size
  • Hydrogels
  • Humans
  • Drug Delivery Systems
  • Biocompatible Materials
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Dimatteo, R., Darling, N. J., & Segura, T. (2018). In situ forming injectable hydrogels for drug delivery and wound repair. Advanced Drug Delivery Reviews, 127, 167–184. https://doi.org/10.1016/j.addr.2018.03.007
Dimatteo, Robert, Nicole J. Darling, and Tatiana Segura. “In situ forming injectable hydrogels for drug delivery and wound repair.Advanced Drug Delivery Reviews 127 (March 2018): 167–84. https://doi.org/10.1016/j.addr.2018.03.007.
Dimatteo R, Darling NJ, Segura T. In situ forming injectable hydrogels for drug delivery and wound repair. Advanced drug delivery reviews. 2018 Mar;127:167–84.
Dimatteo, Robert, et al. “In situ forming injectable hydrogels for drug delivery and wound repair.Advanced Drug Delivery Reviews, vol. 127, Mar. 2018, pp. 167–84. Epmc, doi:10.1016/j.addr.2018.03.007.
Dimatteo R, Darling NJ, Segura T. In situ forming injectable hydrogels for drug delivery and wound repair. Advanced drug delivery reviews. 2018 Mar;127:167–184.
Journal cover image

Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

March 2018

Volume

127

Start / End Page

167 / 184

Related Subject Headings

  • Wound Healing
  • Tissue Engineering
  • Pharmacology & Pharmacy
  • Particle Size
  • Hydrogels
  • Humans
  • Drug Delivery Systems
  • Biocompatible Materials
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences