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PBDE flame retardants: Toxicokinetics and thyroid hormone endocrine disruption in fish

Publication ,  Journal Article
Noyes, PD; Stapleton, HM
Published in: Endocrine Disruptors
January 1, 2014

Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardant chemicals that have been used in large quantities and are now detected worldwide in humans and wildlife. To complement reviews of effects on human health, this review discusses and synthesizes current evidence of PBDE toxicokinetics and toxicity mechanisms leading to perturbations of thyroid hormone homeostasis in fish. PBDE disruptions to thyroid signaling in fish appear to proceed through multiple pathways involving declines in circulating thyroid hormones, disrupted deiodination activity, hindered hormone transport, and altered transcriptional regulation of genes involved in thyroid hormone production, transport, and genomic signaling. PBDE exposures have also been linked to impacts on reproductive health with reductions in fecundity, spawning, hatching success, and offspring survival observed in some species, as well as impaired fertility. These studies on PBDE mediated hormone disruption in fish can help inform future studies seeking to understand potential developmental effects in humans.

Duke Scholars

Published In

Endocrine Disruptors

DOI

EISSN

2327-3747

Publication Date

January 1, 2014

Volume

2

Issue

1

Start / End Page

e29430-1-e29430-25
 

Citation

APA
Chicago
ICMJE
MLA
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Noyes, P. D., & Stapleton, H. M. (2014). PBDE flame retardants: Toxicokinetics and thyroid hormone endocrine disruption in fish. Endocrine Disruptors, 2(1), e29430-1-e29430-25. https://doi.org/10.4161/endo.29430
Noyes, P. D., and H. M. Stapleton. “PBDE flame retardants: Toxicokinetics and thyroid hormone endocrine disruption in fish.” Endocrine Disruptors 2, no. 1 (January 1, 2014): e29430-1-e29430-25. https://doi.org/10.4161/endo.29430.
Noyes PD, Stapleton HM. PBDE flame retardants: Toxicokinetics and thyroid hormone endocrine disruption in fish. Endocrine Disruptors. 2014 Jan 1;2(1):e29430-1-e29430-25.
Noyes, P. D., and H. M. Stapleton. “PBDE flame retardants: Toxicokinetics and thyroid hormone endocrine disruption in fish.” Endocrine Disruptors, vol. 2, no. 1, Jan. 2014, pp. e29430-1-e29430-25. Scopus, doi:10.4161/endo.29430.
Noyes PD, Stapleton HM. PBDE flame retardants: Toxicokinetics and thyroid hormone endocrine disruption in fish. Endocrine Disruptors. 2014 Jan 1;2(1):e29430-1-e29430-25.

Published In

Endocrine Disruptors

DOI

EISSN

2327-3747

Publication Date

January 1, 2014

Volume

2

Issue

1

Start / End Page

e29430-1-e29430-25