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Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer.

Publication ,  Journal Article
Charaghvandi, RK; Yoo, S; van Asselen, B; Rodrigues, A; van den Bongard, DHJG; Horton, JK
Published in: Clin Transl Radiat Oncol
October 2017

BACKGROUND: Following breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visualization and treatment volume reduction. Single dose preoperative APBI has the potential to improve toxicity profiles, reduce treatment burden and enable in vivo exploration of breast cancer radiogenomics. PURPOSE: Develop practical guidelines for single dose external beam preoperative APBI. METHODS: Recommended dose constraints were derived from pooled dosimetry estimates from 2 clinical trials. In an American dose escalation trial, a uniform 15, 18 or 21 Gy dose has previously been evaluated for non-lobular cT1N0 or low/intermediate grade DCIS <2 cm in prone position (n = 32). In the Netherlands, the feasibility of ablative APBI (20 Gy to GTV, 15 Gy to CTV) to non-lobular cT1N0 in supine position, is currently being explored (n = 15). The dosimetric adherence to the developed constraints was evaluated in new APBI plans with a 21 Gy uniform dose but an extended CTV margin (n = 32). RESULTS: Dosimetric data pooling enabled the development of practical guidelines for single dose preoperative APBI. CONCLUSION: The developed guidelines will allow further explorations in the promising field of single dose preoperative external beam APBI for breast cancer treatment.

Duke Scholars

Published In

Clin Transl Radiat Oncol

DOI

EISSN

2405-6308

Publication Date

October 2017

Volume

6

Start / End Page

7 / 14

Location

Ireland

Related Subject Headings

  • 3211 Oncology and carcinogenesis
 

Citation

APA
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ICMJE
MLA
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Charaghvandi, R. K., Yoo, S., van Asselen, B., Rodrigues, A., van den Bongard, D. H. J. G., & Horton, J. K. (2017). Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer. Clin Transl Radiat Oncol, 6, 7–14. https://doi.org/10.1016/j.ctro.2017.06.003
Charaghvandi, Ramona K., Sua Yoo, Bram van Asselen, Anna Rodrigues, Desirée H. J. G. van den Bongard, and Janet K. Horton. “Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer.Clin Transl Radiat Oncol 6 (October 2017): 7–14. https://doi.org/10.1016/j.ctro.2017.06.003.
Charaghvandi RK, Yoo S, van Asselen B, Rodrigues A, van den Bongard DHJG, Horton JK. Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer. Clin Transl Radiat Oncol. 2017 Oct;6:7–14.
Charaghvandi, Ramona K., et al. “Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer.Clin Transl Radiat Oncol, vol. 6, Oct. 2017, pp. 7–14. Pubmed, doi:10.1016/j.ctro.2017.06.003.
Charaghvandi RK, Yoo S, van Asselen B, Rodrigues A, van den Bongard DHJG, Horton JK. Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer. Clin Transl Radiat Oncol. 2017 Oct;6:7–14.
Journal cover image

Published In

Clin Transl Radiat Oncol

DOI

EISSN

2405-6308

Publication Date

October 2017

Volume

6

Start / End Page

7 / 14

Location

Ireland

Related Subject Headings

  • 3211 Oncology and carcinogenesis