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Asbestos Fiber Concentrations in the Lungs of Brake Repair Workers: An Updated Analysis Using Several Regression Methods to Handle Nondetectable Measurements.

Publication ,  Journal Article
Liu, Y; Marsh, GM; Roggli, VL
Published in: J Occup Environ Med
July 2018

OBJECTIVES: The aim of the study was to reanalyze an updated database of lung asbestos fiber levels for 21 brake repair workers who died of mesothelioma using robust maximum likelihood-based regression methods to address nondetectable measurements. METHODS: We applied bivariate normal regression to address the doubly left-censored situation where both the lung fiber concentration of noncommercial (TAA) and commercial amphiboles (AC) were subject to detection limits. For the single left-censored situation, we applied censored normal regression to study the relationship between duration of employment (DOE) and TAA. RESULTS: We found a statistically significant positive relationship between TAA and AC (β = 0.49, 95% confidence interval [CI], 0.11 to 0.86) and a not statistically significant relationship between DOE and TAA (β = 0.02, 95% CI, -0.03 to 0.06). CONCLUSIONS: Our results provide additional support for the conclusion that exposure to commercial amphibole asbestos, and not chrysotile, is related to the occurrence of mesothelioma among some brake workers.

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Published In

J Occup Environ Med

DOI

EISSN

1536-5948

Publication Date

July 2018

Volume

60

Issue

7

Start / End Page

661 / 671

Location

United States

Related Subject Headings

  • Regression Analysis
  • Pleural Neoplasms
  • Peritoneal Neoplasms
  • Occupational Exposure
  • Occupational Diseases
  • Middle Aged
  • Mesothelioma
  • Maintenance
  • Lung
  • Limit of Detection
 

Citation

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Liu, Y., Marsh, G. M., & Roggli, V. L. (2018). Asbestos Fiber Concentrations in the Lungs of Brake Repair Workers: An Updated Analysis Using Several Regression Methods to Handle Nondetectable Measurements. J Occup Environ Med, 60(7), 661–671. https://doi.org/10.1097/JOM.0000000000001320
Liu, Yimeng, Gary M. Marsh, and Victor L. Roggli. “Asbestos Fiber Concentrations in the Lungs of Brake Repair Workers: An Updated Analysis Using Several Regression Methods to Handle Nondetectable Measurements.J Occup Environ Med 60, no. 7 (July 2018): 661–71. https://doi.org/10.1097/JOM.0000000000001320.
Liu, Yimeng, et al. “Asbestos Fiber Concentrations in the Lungs of Brake Repair Workers: An Updated Analysis Using Several Regression Methods to Handle Nondetectable Measurements.J Occup Environ Med, vol. 60, no. 7, July 2018, pp. 661–71. Pubmed, doi:10.1097/JOM.0000000000001320.

Published In

J Occup Environ Med

DOI

EISSN

1536-5948

Publication Date

July 2018

Volume

60

Issue

7

Start / End Page

661 / 671

Location

United States

Related Subject Headings

  • Regression Analysis
  • Pleural Neoplasms
  • Peritoneal Neoplasms
  • Occupational Exposure
  • Occupational Diseases
  • Middle Aged
  • Mesothelioma
  • Maintenance
  • Lung
  • Limit of Detection