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Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors.

Publication ,  Journal Article
Moris, D; Ntanasis-Stathopoulos, I; Tsilimigras, DI; Adam, MA; Yang, C-FJ; Harpole, D; Theocharis, S
Published in: Cancer Genomics Proteomics
2018

Primary lung neuroendocrine tumors (NETs) consist of typical and atypical carcinoids, large-cell neuroendocrine carcinomas and small-cell lung carcinomas. NETs are highly heterogeneous in histological characteristics, clinical presentation and natural history. While there are morphological and immunohistochemical criteria to establish diagnosis, there is a lack of universal consensus for prognostic factors or therapeutic targets for personalized treatment of the disease. Thus, identifying potential markers of neuroendocrine differentiation and prognostic factors remains of high importance. This review provides an insight into promising molecules and genes that are implicated in NET carcinogenesis, cell-cycle regulation, chromatin remodeling, apoptosis, intracellular cascades and cell-cell interactions. Additionally it supports a basis for classifying these tumors into categories that distinct molecular characteristics and disease natural history, which may have a direct impact on treatment options. In light of the recent approval of everolimus, mammalian target of rapamycin pathway inhibition and related biomarkers may play a central role in the treatment of pulmonary NETs. Future clinical trials that integrate molecular profiling are deemed necessary in order to treat patients with NET on a personalized basis.

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Published In

Cancer Genomics Proteomics

DOI

EISSN

1790-6245

Publication Date

2018

Volume

15

Issue

2

Start / End Page

153 / 163

Location

Greece

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroendocrine Tumors
  • Lung Neoplasms
  • Humans
  • Biomarkers
  • Apoptosis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
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Moris, D., Ntanasis-Stathopoulos, I., Tsilimigras, D. I., Adam, M. A., Yang, C.-F., Harpole, D., & Theocharis, S. (2018). Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors. Cancer Genomics Proteomics, 15(2), 153–163. https://doi.org/10.21873/cgp.20073
Moris, Dimitrios, Ioannis Ntanasis-Stathopoulos, Diamantis I. Tsilimigras, Mohamad A. Adam, Chi-Fu Jeffrey Yang, David Harpole, and Stamatios Theocharis. “Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors.Cancer Genomics Proteomics 15, no. 2 (2018): 153–63. https://doi.org/10.21873/cgp.20073.
Moris D, Ntanasis-Stathopoulos I, Tsilimigras DI, Adam MA, Yang C-FJ, Harpole D, et al. Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors. Cancer Genomics Proteomics. 2018;15(2):153–63.
Moris, Dimitrios, et al. “Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors.Cancer Genomics Proteomics, vol. 15, no. 2, 2018, pp. 153–63. Pubmed, doi:10.21873/cgp.20073.
Moris D, Ntanasis-Stathopoulos I, Tsilimigras DI, Adam MA, Yang C-FJ, Harpole D, Theocharis S. Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors. Cancer Genomics Proteomics. 2018;15(2):153–163.

Published In

Cancer Genomics Proteomics

DOI

EISSN

1790-6245

Publication Date

2018

Volume

15

Issue

2

Start / End Page

153 / 163

Location

Greece

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Neuroendocrine Tumors
  • Lung Neoplasms
  • Humans
  • Biomarkers
  • Apoptosis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1107 Immunology