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Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals.

Publication ,  Journal Article
Hostler, CJ; Moehring, RW; Ashley, ESD; Johnson, M; Davis, A; Lewis, SS; Sexton, DJ; Anderson, DJ; CDC Prevention Epicenters Program
Published in: Infect Control Hosp Epidemiol
June 2018
Published version (DOI) Link to item

OBJECTIVETo determine the feasibility and value of developing a regional antibiogram for community hospitals.DESIGNMulticenter retrospective analysis of antibiograms.SETTING AND PARTICIPANTSA total of 20 community hospitals in central and eastern North Carolina and south central Virginia participated in this study.METHODSWe combined antibiogram data from participating hospitals for 13 clinically relevant gram-negative pathogen-antibiotic combinations. From this combined antibiogram, we developed a regional antibiogram based on the mean susceptibilities of the combined data.RESULTSWe combined a total of 69,778 bacterial isolates across 13 clinically relevant gram-negative pathogen-antibiotic combinations (median for each combination, 1100; range, 174-27,428). Across all pathogen-antibiotic combinations, 69% of local susceptibility rates fell within 1 SD of the regional mean susceptibility rate, and 97% of local susceptibilities fell within 2 SD of the regional mean susceptibility rate. No individual hospital had >1 pathogen-antibiotic combination with a local susceptibility rate >2 SD of the regional mean susceptibility rate. All hospitals' local susceptibility rates were within 2 SD of the regional mean susceptibility rate for low-prevalence pathogens (<500 isolates cumulative for the region).CONCLUSIONSSmall community hospitals frequently cannot develop an accurate antibiogram due to a paucity of local data. A regional antibiogram is likely to provide clinically useful information to community hospitals for low-prevalence pathogens.Infect Control Hosp Epidemiol 2018;39:718-722.

Duke Scholars

Elizabeth Dodds Ashley
Author Elizabeth Dodds Ashley Medicine, Infectious Diseases
Melissa DePaoli Johnson
Author Melissa DePaoli Johnson Medicine, Infectious Diseases
Christopher James Hostler
Author Christopher James Hostler Medicine, Infectious Diseases
Rebekah Moehring
Author Rebekah Moehring Medicine, Infectious Diseases
Sarah Stamps Lewis
Author Sarah Stamps Lewis Medicine, Infectious Diseases
Daniel John Sexton
Author Daniel John Sexton Medicine, Infectious Diseases
Deverick John Anderson
Author Deverick John Anderson Medicine, Infectious Diseases
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Published In

Infect Control Hosp Epidemiol

DOI

10.1017/ice.2018.71

EISSN

1559-6834

Publication Date

June 2018

Volume

39

Issue

6

Start / End Page

718 / 722

Location

United States

Related Subject Headings

  • Virginia
  • Retrospective Studies
  • North Carolina
  • Microbial Sensitivity Tests
  • Humans
  • Hospitals, Community
  • Gram-Negative Bacteria
  • Escherichia coli
  • Epidemiology
  • Anti-Bacterial Agents
 

Citation

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Hostler, C. J., Moehring, R. W., Ashley, E. S. D., Johnson, M., Davis, A., Lewis, S. S., … CDC Prevention Epicenters Program. (2018). Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals. Infect Control Hosp Epidemiol, 39(6), 718–722. https://doi.org/10.1017/ice.2018.71
Hostler, Christopher J., Rebekah W. Moehring, Elizabeth S Dodds Ashley, Melissa Johnson, Angelina Davis, Sarah S. Lewis, Daniel J. Sexton, Deverick J. Anderson, and CDC Prevention Epicenters Program. “Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals.” Infect Control Hosp Epidemiol 39, no. 6 (June 2018): 718–22. https://doi.org/10.1017/ice.2018.71.
Hostler CJ, Moehring RW, Ashley ESD, Johnson M, Davis A, Lewis SS, et al. Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals. Infect Control Hosp Epidemiol. 2018 Jun;39(6):718–22.
Hostler, Christopher J., et al. “Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals.” Infect Control Hosp Epidemiol, vol. 39, no. 6, June 2018, pp. 718–22. Pubmed, doi:10.1017/ice.2018.71.
Hostler CJ, Moehring RW, Ashley ESD, Johnson M, Davis A, Lewis SS, Sexton DJ, Anderson DJ, CDC Prevention Epicenters Program. Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals. Infect Control Hosp Epidemiol. 2018 Jun;39(6):718–722.
Journal cover image

Published In

Infect Control Hosp Epidemiol

DOI

10.1017/ice.2018.71

EISSN

1559-6834

Publication Date

June 2018

Volume

39

Issue

6

Start / End Page

718 / 722

Location

United States

Related Subject Headings

  • Virginia
  • Retrospective Studies
  • North Carolina
  • Microbial Sensitivity Tests
  • Humans
  • Hospitals, Community
  • Gram-Negative Bacteria
  • Escherichia coli
  • Epidemiology
  • Anti-Bacterial Agents