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The now and then of gut-brain signaling.

Publication ,  Journal Article
Kaelberer, MM; Bohórquez, DV
Published in: Brain Res
August 15, 2018

Since their very beginnings, animals had gut sensory epithelial cells. In one of the first multicellular animals, Trichoplax - a literal wandering gut - food sensing and feeding was coordinated by specialized ventral sensor cells. In mammals, including humans, gut epithelial sensor cells (a.k.a enteroendocrine cells) have been recognized for an array of neuropeptides, like ghrelin and cholecystokinin, that modulate hunger or satiety. Indeed, since first described as "clear cells" by Rudfolf Heidenhain (1868), research efforts increasingly focused on their hormone neuropeptides leading to the alphabetical classification of one cell-one hormone (e.g. I-cell synthesizes only cholecystokinin). A recent explosion of molecular tools to study the biology of single cells is expanding the imagination of studies and unveiling intriguing aspects of gut sensory transduction. To mention a few: multimodal sensing, one cell expressing both ghrelin and cholecystokinin-the yin and yang of appetite-, and synapses with nerves. This brief account examines recent advances on gut sensory transduction to highlight how food and bacteria in the gut alter eating.

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Published In

Brain Res

DOI

EISSN

1872-6240

Publication Date

August 15, 2018

Volume

1693

Issue

Pt B

Start / End Page

192 / 196

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Neuropeptides
  • Neurology & Neurosurgery
  • Humans
  • Gastrointestinal Tract
  • Epithelial Cells
  • Enteric Nervous System
  • Brain
  • Animals
  • 5202 Biological psychology
 

Citation

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ICMJE
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Kaelberer, M. M., & Bohórquez, D. V. (2018). The now and then of gut-brain signaling. Brain Res, 1693(Pt B), 192–196. https://doi.org/10.1016/j.brainres.2018.03.027
Kaelberer, Melanie M., and Diego V. Bohórquez. “The now and then of gut-brain signaling.Brain Res 1693, no. Pt B (August 15, 2018): 192–96. https://doi.org/10.1016/j.brainres.2018.03.027.
Kaelberer MM, Bohórquez DV. The now and then of gut-brain signaling. Brain Res. 2018 Aug 15;1693(Pt B):192–6.
Kaelberer, Melanie M., and Diego V. Bohórquez. “The now and then of gut-brain signaling.Brain Res, vol. 1693, no. Pt B, Aug. 2018, pp. 192–96. Pubmed, doi:10.1016/j.brainres.2018.03.027.
Kaelberer MM, Bohórquez DV. The now and then of gut-brain signaling. Brain Res. 2018 Aug 15;1693(Pt B):192–196.
Journal cover image

Published In

Brain Res

DOI

EISSN

1872-6240

Publication Date

August 15, 2018

Volume

1693

Issue

Pt B

Start / End Page

192 / 196

Location

Netherlands

Related Subject Headings

  • Signal Transduction
  • Neuropeptides
  • Neurology & Neurosurgery
  • Humans
  • Gastrointestinal Tract
  • Epithelial Cells
  • Enteric Nervous System
  • Brain
  • Animals
  • 5202 Biological psychology