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Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection.

Publication ,  Journal Article
Midani, FS; Weil, AA; Chowdhury, F; Begum, YA; Khan, AI; Debela, MD; Durand, HK; Reese, AT; Nimmagadda, SN; Silverman, JD; Ellis, CN; Ryan, ET ...
Published in: J Infect Dis
July 13, 2018

BACKGROUND: Cholera is a public health problem worldwide, and the risk factors for infection are only partially understood. METHODS: We prospectively studied household contacts of patients with cholera to compare those who were infected to those who were not. We constructed predictive machine learning models of susceptibility, using baseline gut microbiota data. We identified bacterial taxa associated with susceptibility to Vibrio cholerae infection and tested these taxa for interactions with V. cholerae in vitro. RESULTS: We found that machine learning models based on gut microbiota, as well as models based on known clinical and epidemiological risk factors, predicted V. cholerae infection. A predictive gut microbiota of roughly 100 bacterial taxa discriminated between contacts who developed infection and those who did not. Susceptibility to cholera was associated with depleted levels of microbes from the phylum Bacteroidetes. By contrast, a microbe associated with cholera by our modeling framework, Paracoccus aminovorans, promoted the in vitro growth of V. cholerae. Gut microbiota structure, clinical outcome, and age were also linked. CONCLUSION: These findings support the hypothesis that abnormal gut microbial communities are a host factor related to V. cholerae susceptibility.

Duke Scholars

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

July 13, 2018

Volume

218

Issue

4

Start / End Page

645 / 653

Location

United States

Related Subject Headings

  • Young Adult
  • Vibrio cholerae
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Microbiota
  • Microbiology
  • Male
  • Machine Learning
  • Humans
 

Citation

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Midani, F. S., Weil, A. A., Chowdhury, F., Begum, Y. A., Khan, A. I., Debela, M. D., … LaRocque, R. C. (2018). Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. J Infect Dis, 218(4), 645–653. https://doi.org/10.1093/infdis/jiy192
Midani, Firas S., Ana A. Weil, Fahima Chowdhury, Yasmin A. Begum, Ashraful I. Khan, Meti D. Debela, Heather K. Durand, et al. “Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection.J Infect Dis 218, no. 4 (July 13, 2018): 645–53. https://doi.org/10.1093/infdis/jiy192.
Midani FS, Weil AA, Chowdhury F, Begum YA, Khan AI, Debela MD, et al. Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. J Infect Dis. 2018 Jul 13;218(4):645–53.
Midani, Firas S., et al. “Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection.J Infect Dis, vol. 218, no. 4, July 2018, pp. 645–53. Pubmed, doi:10.1093/infdis/jiy192.
Midani FS, Weil AA, Chowdhury F, Begum YA, Khan AI, Debela MD, Durand HK, Reese AT, Nimmagadda SN, Silverman JD, Ellis CN, Ryan ET, Calderwood SB, Harris JB, Qadri F, David LA, LaRocque RC. Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. J Infect Dis. 2018 Jul 13;218(4):645–653.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

July 13, 2018

Volume

218

Issue

4

Start / End Page

645 / 653

Location

United States

Related Subject Headings

  • Young Adult
  • Vibrio cholerae
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Microbiota
  • Microbiology
  • Male
  • Machine Learning
  • Humans